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[KO Validated] HuR/ELAVL1 Rabbit Polyclonal Antibody (CAB6089)

SKU:
CAB6089
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-HuR / ELAVL1 Antibody CAB6089KO Validated
  • KO Validated Antibodies 1 Anti-HuR / ELAVL1 Antibody CAB6089KO Validated
  • KO Validated Antibodies 1 Anti-HuR / ELAVL1 Antibody CAB6089KO Validated
  • KO Validated Antibodies 1 Anti-HuR / ELAVL1 Antibody CAB6089KO Validated
  • KO Validated Antibodies 1 Anti-HuR / ELAVL1 Antibody CAB6089KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] HuR/ELAVL1 Rabbit Polyclonal Antibody
SKU:CAB6089
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HuR/ELAVL1 (NP_001410.2).
Sequence:MSNG YEDH MAED CRGD IGRT NLIV NYLP QNMT QDEL RSLF SSIG EVES AKLI RDKV AGHS LGYG FVNY VTAK DAER AINT LNGL RLQS KTIK VSYA RPSS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:HUR; Hua; MelG; ELAV1; L1
Positive Sample:HeLa,MCF-7,Jurkat,293T,Mouse spleen,Mouse thymus
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:36kDa
Observed MW:36kDa

The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.

Purification Method:Affinity purification
Gene ID:1994
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] HuR/ELAVL1 Rabbit pAb (CAB6089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.

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