CHGB
CHGB (chromogranin B), also known as secretogranin-1, SgI and SCG1, is a neuroendocrine secretory granule protein that may act as a precursor for biologically active peptides. It belongs to the granin group and is abundant in peptidergic endocrine cells and neurons. Browse Assay Genie's current range of CHGB research reagents below, or read on for the biology behind the target.
CHGB is a neuroendocrine secretory granule protein. According to UniProt annotation, it may be the precursor for other biologically active peptides, and the NCBI Gene summary similarly describes it as a protein that may serve as a precursor for regulatory peptides. Its recognised role is therefore tied to the secretory pathway of neuroendocrine cells, where it is found in secretory granules and is released from the cell.
The CHGB gene encodes a tyrosine-sulfated secretory protein that is abundant in peptidergic endocrine cells and neurons. This distribution makes the CHGB protein a useful reference point for researchers studying peptide-secreting cell types. The protein belongs to the chromogranin/secretogranin family, and HGNC classifies the gene within the granins group. The mouse and rat orthologues are both named Chgb.
The protein has been known by several names. HGNC records the approved name as chromogranin B, with the previous name secretogranin 1 and the aliases SgI and SCG1. UniProt lists the recommended protein name as secretogranin-1. These synonyms are worth searching when reviewing the literature on the CHGB gene, since older papers often use the secretogranin designations.
CHGB is a secretory granule protein of neuroendocrine cells, so it is relevant to studies of how these cells package and release their products.
CHGB may be a precursor for biologically active peptides, making it a subject of interest in peptide processing and signalling.
The protein is abundant in neurons and peptidergic endocrine cells, supporting its use in work on these cell populations.
As a member of the chromogranin/secretogranin family, CHGB provides a point of comparison with other granins in the secretory pathway.
CHGB is a neuroendocrine secretory granule protein. UniProt states that it may be the precursor for other biologically active peptides, and NCBI describes it as a possible precursor for regulatory peptides. It is secreted and is abundant in peptidergic endocrine cells and neurons.
CHGB stands for chromogranin B. Its aliases are SgI and SCG1, its previous HGNC name is secretogranin 1, and UniProt uses the protein name secretogranin-1. All of these refer to the same gene and protein product.
Yes. The mouse and rat orthologues are both named Chgb. The protein belongs to the chromogranin/secretogranin family, and HGNC places the gene in the granins group. Check the datasheet of any product for its validated reactivity.
Other granins and neuroendocrine secretory pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05060; product specifications from Assay Genie datasheets.