NR4A1
NR4A1 (nuclear receptor subfamily 4 group A member 1, also known as NUR77, TR3, N10, NAK-1, NGFIB, HMR and GFRP1) is a member of the nuclear hormone receptor family that acts as a nuclear transcription factor and also functions in the cytosol and mitochondria. Browse Assay Genie's current range of NR4A1 research reagents below, or read on for the biology behind the target.
NR4A1 acts as a nuclear transcription factor, but its activity is not confined to the nucleus. In the cytosol, it detects both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released through GSDMD pores during pyroptosis. This dual detection promotes non-canonical NLRP3 inflammasome activation by stimulating the association of NLRP3 and NEK7, placing NR4A1 in innate immune signalling as well as transcriptional control.
The protein belongs to the nuclear hormone receptor family and the NR4 subfamily, and the NR4A1 gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. UniProt records localisation to the nucleus, the cytosol and mitochondria. Translocation of the protein from the nucleus to mitochondria induces apoptosis, so its location shapes its cellular effect. Multiple transcript variants encoding different isoforms have been reported for the gene.
NR4A1 is catalogued by HGNC within the nuclear receptor subfamily 4 group A. It is known by several aliases, including NUR77, TR3, N10, NAK-1, NGFIB, HMR and GFRP1, which reflect its independent discovery in different experimental systems. Mouse and rat orthologs are both designated Nr4a1, which allows comparative work across common model species.
Translocation of NR4A1 from the nucleus to mitochondria induces apoptosis, making it a focus for studies of cell death mechanisms.
NR4A1 promotes non-canonical NLRP3 inflammasome activation by stimulating NLRP3 and NEK7 association during pyroptosis.
As a nuclear transcription factor of the NR4 subfamily, NR4A1 is studied in gene regulation downstream of inducing stimuli.
NR4A1 expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts.
NR4A1 acts as a nuclear transcription factor. In the cytosol it senses LPS and mitochondrial DNA released during pyroptosis and promotes non-canonical NLRP3 inflammasome activation by stimulating NLRP3 and NEK7 association. Its translocation from the nucleus to mitochondria induces apoptosis.
NR4A1 is also called NUR77, TR3, N10, NAK-1, NGFIB, HMR and GFRP1. The previous HGNC name was nuclear receptor subfamily 4, group A, member 1. Multiple transcript variants encoding different isoforms have been described for the gene.
Yes. Mouse and rat both have an ortholog named Nr4a1, so the target can be studied in common rodent models. NR4A1 belongs to the NR4 subfamily of nuclear hormone receptors; check the datasheet of any product for its validated reactivity.
Other NR4 subfamily members, nuclear hormone receptors and nuclear receptor co-regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P22736; product specifications from Assay Genie datasheets.