LMTK3
LMTK3 (lemur tail kinase 3) is a serine/threonine-protein kinase that phosphorylates ESR1 and protects it from proteasomal degradation. It is also known as KIAA1883, LMR3, AATYK3, TYKLM3 and PPP1R101, and is involved in endocytic trafficking of NMDA receptors in neurons. Browse Assay Genie's current range of LMTK3 research reagents below, or read on for the biology behind the target.
LMTK3 is a protein kinase that phosphorylates ESR1 (oestrogen receptor alpha) in vitro and protects it against proteasomal degradation. It may also influence ESR1 levels indirectly through a PKC-AKT-FOXO3 pathway: LMTK3 decreases PKC activity and AKT phosphorylation, which increases binding of the transcriptional activator FOXO3 to the ESR1 promoter and raises ESR1 transcription. In neurons, LMTK3 is involved in the endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR).
The LMTK3 protein belongs to the protein kinase superfamily and the Tyr protein kinase family, and is classified by HGNC in the lemur tail kinase family. Despite that family placement, the enzyme is annotated as a serine/threonine-protein kinase (EC 2.7.11.1). UniProt records it at membranes, in axons and dendrites, and at the Golgi apparatus membrane, which is consistent with the NCBI Gene prediction of localisation to Golgi membrane, axon and dendrite. The mouse ortholog is Lmtk3.
The LMTK3 gene was originally named lemur tyrosine kinase 3, and HGNC also lists it within the protein phosphatase 1 regulatory subunits group under the alias PPP1R101. Other names include KIAA1883, LMR3, AATYK3 and TYKLM3. Researchers studying kinase signalling, oestrogen receptor biology and neuronal receptor trafficking use LMTK3 as a target of interest.
LMTK3 phosphorylates ESR1 and protects it from proteasomal degradation, making it relevant to studies of ESR1 stability and regulation.
LMTK3 may lower PKC activity and AKT phosphorylation, increasing FOXO3 binding to the ESR1 promoter and ESR1 transcription.
LMTK3 is involved in endocytic trafficking of NMDA receptors in neurons, linking it to research on synaptic receptor regulation.
As a membrane-associated kinase found in axons, dendrites and Golgi membrane, LMTK3 is a subject for cell biology and kinase family research.
LMTK3 is a protein kinase that phosphorylates ESR1 in vitro and protects it against proteasomal degradation. It may also affect ESR1 transcription through a PKC-AKT-FOXO3 pathway, and it is involved in endocytic trafficking of NMDA receptors in neurons.
LMTK3 stands for lemur tail kinase 3, previously named lemur tyrosine kinase 3. Aliases include KIAA1883, LMR3, AATYK3, TYKLM3 and PPP1R101. UniProt names the protein serine/threonine-protein kinase LMTK3.
A mouse ortholog, Lmtk3, is recorded for the human LMTK3 gene. Cross-reactivity of any reagent with other species varies, so check the datasheet of any product for its validated reactivity.
Lemur tail kinase relatives, ESR1 pathway components and NMDA receptor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96Q04; product specifications from Assay Genie datasheets.