ERF
ERF (ETS2 repressor factor, also known as PE-2 or PE2) is a nuclear, ETS domain-containing transcription factor. It acts as a potent repressor that binds the H1 element of the ETS2 promoter and may regulate other genes involved in cellular proliferation. Browse Assay Genie's current range of ERF research reagents below, or read on for the biology behind the target.
ERF is a potent transcriptional repressor. It binds to the H1 element of the Ets2 promoter and is a strong repressor of ETS2 transcription. ETS2 is itself a transcription factor and protooncogene involved in development, apoptosis and the regulation of telomerase, so ERF sits upstream of a regulator with broad biological roles. UniProt also notes that ERF may regulate other genes involved in cellular proliferation.
The protein is localised to the nucleus and belongs to the ETS family; HGNC places the ERF gene in the ETS transcription factor family. The human protein is catalogued as UniProt P50548, and the mouse ortholog is Erf. According to the NCBI Gene summary, several transcript variants of the ERF gene encode two different isoforms.
In developmental terms, ERF is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure and chorioallantoic attachment. It may also be important for regulating trophoblast stem cell differentiation. The name reflects its original description as a repressor of ETS2, and HGNC lists the previous name as Ets2 repressor factor, with PE-2 and PE2 as earlier symbols. Researchers studying ERF commonly focus on transcriptional repression, proliferation control and placental development.
ERF is a potent repressor that binds the H1 element of the Ets2 promoter, making it a model for ETS-mediated gene silencing.
ERF may regulate other genes involved in cellular proliferation, linking it to studies of growth control.
ERF is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure and chorioallantoic attachment.
ERF may be important for regulating trophoblast stem cell differentiation, relevant to early developmental biology.
ERF is a nuclear transcription factor that acts as a potent repressor. It binds the H1 element of the Ets2 promoter and strongly represses ETS2 transcription. It may also regulate other genes involved in cellular proliferation, and it contributes to extraembryonic development.
ERF stands for ETS2 repressor factor; previous HGNC names and symbols include Ets2 repressor factor, PE-2 and PE2. The UniProt entry is named ETS domain-containing transcription factor ERF. NCBI Gene reports several transcript variants encoding two different isoforms.
A mouse ortholog, Erf, is recognised. The UniProt function annotation states ERF is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure and chorioallantoic attachment. Check the datasheet of any product for its validated reactivity.
Other ETS family transcription factors and ETS2 pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50548; product specifications from Assay Genie datasheets.