TFCP2
TFCP2 (transcription factor CP2, also known as SEF, CP2, LSF, LBP-1C and TFCP2C) is a nuclear transcription factor that binds the alpha-globin promoter and regulates erythroid gene expression. It also acts on many other cellular and viral promoters. Browse Assay Genie's current range of TFCP2 research reagents below, or read on for the biology behind the target.
TFCP2 is a DNA-binding transcription factor that recognises a variety of cellular and viral promoters, including those of fibrinogen, alpha-globin, SV40 and HIV-1. In erythroid cells it activates the alpha-globin promoter through synergistic interaction with UBP1. It also works as part of the SSP (stage selector protein) complex, which helps set the pattern of globin gene expression during development.
Within the SSP complex, TFCP2 binds the stage selector element (SSE) in the proximal gamma-globin promoter. This binding facilitates the interaction of the gamma-globin genes with enhancer elements in the locus control region in foetal erythroid cells. NCBI Gene summarises the protein as a regulator of erythroid gene expression that plays a role in the transcriptional switch of globin gene promoters. Researchers studying globin regulation therefore often work with the TFCP2 protein and gene. The protein localises to the nucleus.
TFCP2 belongs to the grh/CP2 family, CP2 subfamily, and HGNC places the gene in the transcription factor CP2 family. The UniProt recommended name is alpha-globin transcription factor CP2, and the gene is also known by the aliases SEF, CP2, LSF, LBP-1C and TFCP2C. The mouse ortholog is Tfcp2. According to NCBI Gene, the gene product interacts with certain inflammatory response factors, and polymorphisms of the gene may be involved in the pathogenesis of Alzheimer's disease. This makes TFCP2 relevant beyond erythroid biology, and a TFCP2 antibody or TFCP2 ELISA kit can support work in either area.
TFCP2 binds the alpha-globin promoter and takes part in the transcriptional switch of globin gene promoters.
TFCP2 regulates erythroid gene expression and cooperates with UBP1 to activate the alpha-globin promoter in erythroid cells.
TFCP2 binds viral promoters including SV40 and HIV-1, making it relevant to studies of viral transcription.
TFCP2 interacts with certain inflammatory response factors, and its polymorphisms may be involved in Alzheimer's disease pathogenesis.
TFCP2 is a transcription factor that binds many cellular and viral promoters, including alpha-globin, fibrinogen, SV40 and HIV-1. It activates alpha-globin transcription in erythroid cells with UBP1 and acts within the SSP complex at the gamma-globin promoter in foetal erythroid cells.
TFCP2 is also called SEF, CP2, LSF, LBP-1C and TFCP2C. HGNC names it transcription factor CP2, while UniProt uses alpha-globin transcription factor CP2. Check which alias a publication uses when comparing literature on this gene.
A mouse ortholog, Tfcp2, exists. TFCP2 belongs to the grh/CP2 family. NCBI Gene reports that polymorphisms of the gene may be involved in the pathogenesis of Alzheimer's disease; check the datasheet of any product for its validated reactivity.
Other grh/CP2 family transcription factors and globin regulation partners that may be of interest alongside TFCP2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12800; product specifications from Assay Genie datasheets.