ANOS1
ANOS1 (anosmin 1, also known as KAL1, KAL, KALIG-1, WFDC19 and ADMLX) is a cell surface and secreted protein with branch-promoting and guidance activity in the developing olfactory system. Mutations in the ANOS1 gene cause X-linked Kallmann syndrome. Browse Assay Genie's current range of ANOS1 research reagents below, or read on for the biology behind the target.
ANOS1 has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. It also acts as a chemoattractant for foetal olfactory epithelial cells. These properties place the protein within the cellular machinery that organises how olfactory neurons and their projections are arranged during development.
Anosmin-1 is found at the cell membrane and is also secreted. The NCBI Gene summary describes it as a cell surface protein that is N-glycosylated and that may have anti-protease activity. Its sequence is similar to proteins known to function in neural cell adhesion and axonal migration, which is consistent with its role in guidance. HGNC classifies the gene within the WAP four-disulfide core domain containing and fibronectin type III domain containing groups.
The ANOS1 gene was formerly named the Kallmann syndrome 1 sequence, and the symbols KAL1, KAL, KALIG-1, WFDC19 and ADMLX appear in older literature and databases. These names reflect its disease association: mutations in the gene cause X-linked Kallmann syndrome. Researchers studying ANOS1 protein therefore work at the intersection of neural development, olfactory biology and the genetics of this disorder.
ANOS1 may contribute to patterning mitral and tufted cell collaterals to the olfactory cortex, making it a focus for olfactory circuit studies.
Mutations in the ANOS1 gene cause X-linked Kallmann syndrome, so the protein is central to studies of this inherited disorder.
The protein resembles neural cell adhesion and axonal migration factors and shows combined branch-promoting and guidance activity.
Anosmin-1 acts as a chemoattractant for foetal olfactory epithelial cells, supporting work on directed cell movement.
ANOS1 has a dual branch-promoting and guidance activity that may be important in patterning mitral and tufted cell collaterals to the olfactory cortex. It is also a chemoattractant for foetal olfactory epithelial cells, and it may have anti-protease activity.
ANOS1 is also known as anosmin-1, anosmin 1, KAL1, KAL, KALIG-1, WFDC19 and ADMLX. Its previous HGNC name was Kallmann syndrome 1 sequence. Older papers and database records often use KAL1, so search several names when reviewing the literature.
Mutations in the ANOS1 gene cause X-linked Kallmann syndrome, according to the NCBI Gene summary. The protein is N-glycosylated, located at the cell surface and secreted, and resembles proteins involved in neural cell adhesion and axonal migration.
Other neural guidance, cell adhesion and developmental biology targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23352; product specifications from Assay Genie datasheets.