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Anti-KAL1 Antibody (CAB16389)

SKU:
CAB16389
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-KAL1 Antibody CAB16389
  • Cell Biology Antibodies 7 Anti-KAL1 Antibody CAB16389
  • Cell Biology Antibodies 7 Anti-KAL1 Antibody CAB16389
  • Cell Biology Antibodies 7 Anti-KAL1 Antibody CAB16389
  • Cell Biology Antibodies 7 Anti-KAL1 Antibody CAB16389
€139 - €419
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Description

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Antibody Name:Anti-KAL1 Antibody
Antibody SKU:CAB16389
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human KAL1 (NP_000207.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human KAL1 (NP_000207.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LEVK WSSK FNIS IEPV IYVV QRRW NYGI HPSE DDAT HWQT VAQT TDER VQLT DIRP SRWY QFRV AAVN VHGT RGFT APSK HFRS SKDP SAPP APAN LRLA N
Gene ID:3730
Uniprot:P23352
Cellular Location:Cell membrane, Peripheral membrane protein, Secreted
Calculated MW:76kDa
Observed MW:76kDa
Synonyms:ANOS1, ADMLX, HH1, HHA, KAL, KAL1, KALIG-1, KMS, WFDC19, anosmin-1
Background:Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity.
UniProt Protein Function:KAL1: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. Chemoattractant for fetal olfactory epithelial cells. Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: Xp22.32

Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function:extracellular matrix structural constituent; protein binding

Biological Process: axon guidance; cell motility; chemotaxis; fibroblast growth factor receptor signaling pathway

Disease: Hypogonadotropic Hypogonadism 1 With Or Without Anosmia

NCBI Summary:Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
UniProt Code:P23352
NCBI GenInfo Identifier:134048661
NCBI Gene ID:3730
NCBI Accession:P23352.3
UniProt Secondary Accession:P23352,B2RPF8,
UniProt Related Accession:P23352
Molecular Weight:76,112 Da
NCBI Full Name:Anosmin-1
NCBI Synonym Full Names:anosmin 1
NCBI Official Symbol:ANOS1  
NCBI Official Synonym Symbols:HH1; HHA; KAL; KMS; KAL1; ADMLX; WFDC19; KALIG-1  
NCBI Protein Information:anosmin-1
UniProt Protein Name:Anosmin-1
UniProt Synonym Protein Names:Adhesion molecule-like X-linked; Kallmann syndrome protein
UniProt Gene Name:ANOS1  
UniProt Entry Name:KALM_HUMAN
Anti-KAL1 Antibody (CAB16389)Western blot analysis of extracts of various cell lines, using KAL1 Rabbit pAb (CAB16389) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-KAL1 Antibody (CAB16389)Immunofluorescence analysis of rat brain using KAL1 antibody (CAB16389) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-KAL1 Antibody (CAB16389)Immunofluorescence analysis of rat brain using KAL1 antibody (CAB16389) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-KAL1 Antibody (CAB16389)Immunofluorescence analysis of mouse brain using KAL1 antibody (CAB16389) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-KAL1 Antibody (CAB16389)Immunofluorescence analysis of mouse brain using KAL1 antibody (CAB16389) at dilution of 1:100. Blue: DAPI for nuclear staining.

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