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Anti-TIAM1 Antibody (CAB10252)

SKU:
CAB10252
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
€139 - €419
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Description

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Antibody Name:Anti-TIAM1 Antibody
Antibody SKU:CAB10252
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2).
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SILR DKHR RQLL KTES LPSS QQYV PFGG KRLC ALKG ARPA MSRA VSAP SKSL GRRR RRLA RNRF TIDS DAVS ASSP EKES QQPP GGGD TDRW VEEQ FDLA QYEE QDDI KETD ILSD DDEF CESV KGAS VDRD LQER LQAT SISQ RERG RKTL DSHA SRMA QLKK QAAL SGIN GGLE SASE EVIW VRRE DFAP SRKL NTEI
Gene ID:7074
Uniprot:Q13009
Cellular Location:Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein
Calculated MW:170kDa/177kDa
Observed MW:250KDa
Synonyms:TIAM1
Background:
UniProt Protein Function:TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes.
UniProt Protein Details:

Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane

Molecular Function:guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction

UniProt Code:Q13009
NCBI GenInfo Identifier:152031709
NCBI Gene ID:7074
NCBI Accession:Q13009.2
UniProt Secondary Accession:Q13009,Q17RT7, B7ZLR6, F5GZ53,
UniProt Related Accession:Q13009
Molecular Weight:178kDa
NCBI Full Name:T-lymphoma invasion and metastasis-inducing protein 1
NCBI Synonym Full Names:T-cell lymphoma invasion and metastasis 1
NCBI Official Symbol:TIAM1  
NCBI Protein Information:T-lymphoma invasion and metastasis-inducing protein 1
UniProt Protein Name:T-lymphoma invasion and metastasis-inducing protein 1
Protein Family:T-lymphoma invasion and metastasis-inducing protein
UniProt Gene Name:TIAM1  
Anti-TIAM1 Antibody (CAB10252)Western blot analysis of extracts of Rat testis, using TIAM1 antibody (CAB10252) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00025). Exposure time: 30s.
Anti-TIAM1 Antibody (CAB10252)Immunohistochemistry of paraffin-embedded human lung cancer using TIAM1 antibody (CAB10252) at dilution of 1:100 (40x lens).
Anti-TIAM1 Antibody (CAB10252)Immunohistochemistry of paraffin-embedded human colon carcinoma using TIAM1 antibody (CAB10252) at dilution of 1:100 (40x lens).

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