FGFBP2
FGFBP2 (fibroblast growth factor binding protein 2, also known as KSP37) is a secreted serum protein and a member of the fibroblast growth factor-binding protein family. It is selectively secreted by cytotoxic lymphocytes and may contribute to cytotoxic lymphocyte-mediated immunity. Browse Assay Genie's current range of FGFBP2 research reagents below, or read on for the biology behind the target.
FGFBP2 is a serum protein that is selectively secreted by cytotoxic lymphocytes. According to the NCBI Gene summary, it may be involved in cytotoxic lymphocyte-mediated immunity. That makes the FGFBP2 protein a point of interest for researchers studying how cytotoxic cells shape immune responses in the extracellular environment. No detailed molecular mechanism is described in the sources used for this page, so its precise biochemical role is still best treated as an open question.
The FGFBP2 gene encodes a member of the fibroblast growth factor binding protein family, a group defined by its relationship to fibroblast growth factor biology. UniProt classifies the product as a secreted protein found in the extracellular space, consistent with its presence in serum. The protein is also known as KSP37, and its full name is fibroblast growth factor-binding protein 2. FGFBP1 is another member of the same family.
In terms of disease relevance, the NCBI Gene summary notes that an increase in the amount of the gene product may be associated with atopic asthma and mild extrinsic asthma. This connects FGFBP2 to allergic and respiratory disease research as well as to the study of lymphocyte-mediated immunity. Researchers measuring FGFBP2 will typically be interested in its secreted, circulating form and in how its abundance relates to cytotoxic lymphocyte activity and asthma phenotypes.
FGFBP2 is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity.
Increased FGFBP2 gene product may be associated with atopic asthma and mild extrinsic asthma.
FGFBP2 is a secreted serum protein found in the extracellular space, making it relevant to circulating protein analysis.
FGFBP2 belongs to the fibroblast growth factor-binding protein family, alongside FGFBP1, supporting comparative family studies.
FGFBP2 is a serum protein selectively secreted by cytotoxic lymphocytes. The NCBI Gene summary states that it may be involved in cytotoxic lymphocyte-mediated immunity. Its exact molecular mechanism is not described in the sources used here, so its function is best described in this immune context.
FGFBP2 stands for fibroblast growth factor binding protein 2, and the protein is listed in UniProt as fibroblast growth factor-binding protein 2. KSP37 is a recognised alias. It belongs to the fibroblast growth factor binding protein family, which also includes FGFBP1.
The NCBI Gene summary reports that an increase in the amount of FGFBP2 gene product may be associated with atopic asthma and mild extrinsic asthma. This is an association rather than an established mechanism. Mouse and rat orthologs are not specified in the data supplied here.
Other members of the fibroblast growth factor binding protein family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BYJ0; product specifications from Assay Genie datasheets.