PPID
PPID (peptidylprolyl isomerase D) is a member of the cyclophilin-type peptidyl-prolyl cis-trans isomerase family. It is also known as CYP-40 and CypD, and the encoded protein catalyses the cis-trans isomerisation of proline imidic peptide bonds. Browse Assay Genie's current range of PPID research reagents below, or read on for the biology behind the target.
PPID belongs to the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyse the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The PPID protein has been shown to possess PPIase activity and, like other family members, can bind the immunosuppressant cyclosporin A. UniProt also notes that it may be involved in hepatitis C virus (HCV) replication and release.
The PPID gene encodes peptidyl-prolyl cis-trans isomerase D, assigned to the cyclophilin-type PPIase family and the PPIase D subfamily. HGNC places it in two gene groups: the cyclophilin peptidylprolyl isomerases and the tetratricopeptide repeat domain containing proteins. In UniProt, the protein is annotated as localised to the cytoplasm and to the nucleus, in both the nucleolus and the nucleoplasm. Orthologous genes, named Ppid, are present in mouse and rat, which allows comparative work in rodent models.
The protein is known by the aliases CYP-40 and CypD, and the approved name was previously written as peptidylprolyl isomerase D (cyclophilin D). Because several cyclophilins share similar names and the same catalytic activity, it is worth confirming the gene symbol and UniProt accession when searching the literature for a PPID antibody, PPID ELISA kit or recombinant PPID protein.
As a PPIase, PPID catalyses proline cis-trans isomerisation, making it a relevant enzyme for studying how proline bond conformation affects protein folding.
PPID belongs to the cyclophilin-type PPIase family, so it is used in comparative work on cyclophilin function and on cyclosporin A binding.
UniProt reports that PPID may be involved in hepatitis C virus replication and release, linking it to host factor research.
HGNC classes PPID among tetratricopeptide repeat domain containing proteins, which makes it of interest to researchers studying this protein group.
PPID is a peptidyl-prolyl cis-trans isomerase. It catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and accelerates protein folding. It can also bind cyclosporin A, and UniProt notes it may be involved in hepatitis C virus replication and release.
PPID is also called CYP-40 and CypD. UniProt lists the protein as peptidyl-prolyl cis-trans isomerase D, and the HGNC name was previously peptidylprolyl isomerase D (cyclophilin D). The enzyme carries the EC number 5.2.1.8.
Yes. Mouse and rat both have an ortholog named Ppid. The protein sits in the cyclophilin-type PPIase family, PPIase D subfamily. Check the datasheet of any product for its validated reactivity.
Other cyclophilin peptidyl-prolyl isomerases and related protein-folding targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08752; product specifications from Assay Genie datasheets.