PACSIN2
PACSIN2 (protein kinase C and casein kinase substrate in neurons 2, also known as SDPII) is a member of the PACSIN family that links the actin cytoskeleton to vesicle formation. It contains F-BAR and SH3 domains and is also exploited by several pathogens during infection. Browse Assay Genie's current range of PACSIN2 research reagents below, or read on for the biology behind the target.
PACSIN2 is involved in linking the actin cytoskeleton with vesicle formation, and it does so by regulating tubulin polymerisation. It belongs to the PACSIN family, whose members are named as substrates of protein kinase C and casein kinase in neurons. In the HGNC classification the PACSIN2 gene sits in the F-BAR domain containing and SH3 domain containing groups.
UniProt records the protein in many cellular compartments: cytoplasm, cytoskeleton, cytoplasmic vesicle membrane, ruffle membrane, early endosome, recycling endosome membrane, cell membrane, caveolae and adherens junctions. This spread fits a role as an adaptor between membrane trafficking and cytoskeletal organisation. The gene undergoes alternative splicing, which produces multiple transcript variants. Mouse and rat both carry an ortholog named Pacsin2.
PACSIN2 also features in host-pathogen biology. In the context of microbial infection, it specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. It promotes protrusion engulfment during cell-to-cell spread of bacterial pathogens such as Listeria monocytogenes. It is also involved in lipid droplet formation, which is important for HCV virion assembly. Related family members, such as PACSIN3, share the PACSIN family designation and are useful comparators when studying isoform-specific functions.
PACSIN2 links the actin cytoskeleton with vesicle formation and regulates tubulin polymerisation, making it a useful target for studying membrane and cytoskeletal coupling.
PACSIN2 specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer, so it is studied in viral transmission mechanisms.
PACSIN2 promotes protrusion engulfment during cell-to-cell spread of bacterial pathogens such as Listeria monocytogenes, which is relevant to infection research.
PACSIN2 is involved in lipid droplet formation, which is important for HCV virion assembly, linking lipid biology to viral replication studies.
PACSIN2 links the actin cytoskeleton with vesicle formation by regulating tubulin polymerisation. It also enhances HIV-1 cell-to-cell spread, promotes protrusion engulfment during Listeria monocytogenes spread, and is involved in lipid droplet formation needed for HCV virion assembly.
PACSIN2 is the approved HGNC symbol for protein kinase C and casein kinase substrate in neurons 2, and SDPII is a listed alias. The gene produces multiple transcript variants through alternative splicing, so reagents may recognise different forms; check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat each have an ortholog named Pacsin2, and the protein belongs to the PACSIN family, which also includes PACSIN3. Orthologs allow PACSIN2 function to be studied in rodent models; check the datasheet of any product for its validated reactivity.
Other PACSIN family members and related F-BAR and SH3 domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UNF0; product specifications from Assay Genie datasheets.