DRAM1
DRAM1 (DNA damage regulated autophagy modulator 1, also known as DRAM or FLJ11259) is a lysosomal membrane protein that modulates autophagy. It acts downstream of the p53 tumour suppressor pathway and plays a central role in p53-mediated apoptosis. Browse Assay Genie's current range of DRAM1 research reagents below, or read on for the biology behind the target.
DRAM1 is a lysosomal modulator of autophagy. According to UniProt, it plays a central role in p53/TP53-mediated apoptosis, but it is not involved in p73/TP73-mediated autophagy. This makes the DRAM1 protein a useful point of comparison when separating the outputs of the p53 and p73 pathways, and when studying how autophagy and cell death are linked.
The DRAM1 gene is regulated as part of the p53 tumour suppressor pathway. NCBI Gene summarises the encoded protein as a lysosomal membrane protein that is required for the induction of autophagy by this pathway. Its subcellular location is the lysosome membrane. The protein belongs to the DRAM/TMEM150 family, and HGNC places the gene in the DRAM autophagy modulator family. The mouse ortholog is Dram1. The human gene also has a pseudogene on chromosome 4.
The name reflects the gene's regulation in response to DNA damage. HGNC lists the previous name as DNA-damage regulated autophagy modulator 1, and the previous symbols and aliases include DRAM and FLJ11259. Decreased transcriptional expression of DRAM1 has been associated with various tumours, so the gene is of interest in cancer biology as well as in studies of lysosomal function and autophagy regulation.
DRAM1 is a lysosomal membrane protein required for autophagy induction by the p53 pathway, so it is relevant to studies of how autophagy is triggered.
DRAM1 plays a central role in p53/TP53-mediated apoptosis, linking this tumour suppressor pathway to autophagy and cell death.
Reduced DRAM1 transcription is associated with various tumours, making it a candidate readout in p53 pathway and cancer research.
As a lysosome membrane protein of the DRAM/TMEM150 family, DRAM1 is relevant to research on lysosomal contributions to autophagy.
DRAM1 is a lysosomal modulator of autophagy. UniProt describes a central role in p53/TP53-mediated apoptosis, and NCBI Gene reports that this lysosomal membrane protein is required for autophagy induction by the p53 pathway. It is not involved in p73/TP73-mediated autophagy.
The HGNC name is DNA damage regulated autophagy modulator 1. Aliases and previous symbols include DRAM and FLJ11259, and the previous name was DNA-damage regulated autophagy modulator 1. UniProt names the protein DNA damage-regulated autophagy modulator protein 1.
The mouse ortholog is Dram1, and the protein belongs to the DRAM/TMEM150 family. NCBI Gene notes that decreased transcriptional expression of DRAM1 is associated with various tumours. Check the datasheet of any product for its validated reactivity.
Other autophagy, p53 pathway and lysosomal membrane targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N682; product specifications from Assay Genie datasheets.