FBLN5
FBLN5 (fibulin 5) is a secreted extracellular matrix protein that is essential for elastic fibre formation. Also known as EVEC, UP50, DANCE and ARMD3, it organises elastic fibres and acts as a vascular ligand for integrin receptors. Browse Assay Genie's current range of FBLN5 research reagents below, or read on for the biology behind the target.
FBLN5 is essential for elastic fibre formation. It is involved in the assembly of a continuous elastin (ELN) polymer and promotes the interaction of microfibrils with ELN. It may act as an adapter that mediates the interaction between FBN1 and ELN. In this way FBLN5 stabilises and organises elastic fibres in the skin, lung and vasculature.
The FBLN5 protein is secreted into the extracellular matrix. It contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains, and it belongs to the fibulin family. Through the RGD motif and integrin interactions, FBLN5 promotes adhesion of endothelial cells. It serves as a vascular ligand for integrin receptors and may play a role in vascular development and remodelling.
FBLN5 expression is prominent in developing arteries but lower in adult vessels. It is reinduced in balloon-injured vessels and in atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Defects in the FBLN5 gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I and age-related macular degeneration type 3 (ARMD3), which explains one of its aliases. The mouse and rat orthologues are both named Fbln5, so the protein can be studied in common rodent models.
FBLN5 is essential for elastic fibre formation and assembly of the elastin polymer, making it central to studies of elastic matrix organisation.
FBLN5 is prominent in developing arteries and is reinduced in injured vessels and atherosclerotic lesions, which links it to vascular remodelling.
Its RGD motif mediates integrin-dependent adhesion of endothelial cells, so FBLN5 is relevant to work on matrix-cell interactions.
Defects in FBLN5 cause forms of cutis laxa and age-related macular degeneration type 3, supporting research into these connective tissue and eye disorders.
FBLN5 is essential for elastic fibre formation. It helps assemble continuous elastin polymer, promotes the interaction of microfibrils with elastin, and stabilises elastic fibres in skin, lung and vasculature. It also promotes endothelial cell adhesion through integrins and its RGD motif.
FBLN5 is the HGNC symbol for fibulin 5, also called Fibulin-5. Aliases include EVEC, UP50, DANCE and ARMD3. The ARMD3 alias reflects the association of gene defects with age-related macular degeneration type 3.
Defects in FBLN5 cause autosomal dominant cutis laxa, autosomal recessive cutis laxa type I and age-related macular degeneration type 3. Mouse and rat both have an orthologue named Fbln5; check the datasheet of any product for its validated reactivity.
Other fibulin family members with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBX5; product specifications from Assay Genie datasheets.