CD207
CD207, also known as Langerin or CLEC4K, is a calcium-dependent C-type lectin with mannose-binding specificity. It is expressed in Langerhans cells and induces the formation of Birbeck granules, supporting antigen uptake and routing. Browse Assay Genie's current range of CD207 research reagents below, or read on for the biology behind the target.
CD207 is a calcium-dependent lectin that displays mannose-binding specificity. It also binds sulfated as well as mannosylated glycans, keratan sulfate and beta-glucans. The protein induces the formation of Birbeck granules and is a potent regulator of membrane superimposition and zippering. It facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. It has been proposed that mannose binding by CD207 leads to internalisation of antigen into Birbeck granules, giving access to a nonclassical antigen-processing pathway.
The CD207 protein is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa. Within these cells it is localised to Birbeck granules, cytoplasmic organelles made up of superimposed and zippered membranes. It is a major receptor on primary Langerhans cells for Candida species, Saccharomyces species and Malassezia furfur.
CD207 also has a role in host defence against viruses. It protects against human immunodeficiency virus-1 (HIV-1) infection by binding high-mannose structures on the viral envelope glycoprotein, then targeting the virus to Birbeck granules, where it is rapidly degraded. Mutations in the CD207 gene result in Birbeck granule deficiency or loss of sugar-binding activity. HGNC classifies it among CD molecules, scavenger receptors and C-type lectin receptors; previous names include CD207 antigen, langerin. The mouse ortholog is Cd207.
CD207 is expressed only in Langerhans cells, immature dendritic cells of the epidermis and mucosa, so it is a defining protein for studying this cell type.
CD207 facilitates antigen uptake and its routing or processing for presentation to T cells, including access to a nonclassical processing pathway.
CD207 is a major receptor on primary Langerhans cells for Candida species, Saccharomyces species and Malassezia furfur.
CD207 binds high-mannose envelope glycoprotein structures and directs HIV-1 to Birbeck granules for rapid degradation, protecting against infection.
CD207 is a calcium-dependent, mannose-binding C-type lectin that induces Birbeck granule formation in Langerhans cells. It facilitates antigen uptake and routing for presentation to T cells, and acts as a receptor for fungi such as Candida and Malassezia furfur. It also protects against HIV-1 infection.
CD207 is also called Langerin and CLEC4K. UniProt names the protein C-type lectin domain family 4 member K, and HGNC lists the gene as CD207 molecule. Earlier names include CD207 antigen, langerin. Researchers may see any of these terms in the literature and on product listings.
A mouse ortholog, Cd207, exists. In humans, mutations in the CD207 gene result in Birbeck granule deficiency or loss of sugar-binding activity. Check the datasheet of any product for its validated reactivity.
Other CD molecules, dendritic cell markers and antigen-presentation targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJ71; product specifications from Assay Genie datasheets.