CILP
CILP (cartilage intermediate layer protein, also known as CILP1 or HsT18872) is a secreted extracellular matrix protein of cartilage. It is thought to contribute to cartilage scaffolding and to antagonise IGF1 and TGF-beta1 signalling. Browse Assay Genie's current range of CILP research reagents below, or read on for the biology behind the target.
CILP is a secreted protein found in the extracellular space and extracellular matrix. It probably plays a role in cartilage scaffolding. It may also act by antagonising TGF-beta1 (TGFB1) and IGF1 function. CILP can suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and it inhibits ligand-induced IGF1R autophosphorylation. Through its interaction with TGF-beta1, it may inhibit TGF-beta1-mediated induction of cartilage matrix genes.
The CILP gene encodes the cartilage intermediate layer protein and is classed by HGNC in the immunoglobulin like domain containing group. Its mouse ortholog is Cilp. The encoded protein was once thought to be a precursor for two proteins, an N-terminal CILP and a C-terminal homologue of nucleotide pyrophosphohydrolase (NTPPHase), which explains the earlier name nucleotide pyrophosphohydrolase. Later studies found no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. Both the full-length protein and its N-terminal domain were shown to function as IGF-1 antagonists.
Cartilage extracellular matrix composition changes markedly in joint disease such as osteoarthrosis, and CILP increases in early osteoarthrosis cartilage. Overexpression may impair chondrocyte growth and matrix repair, and may indirectly promote inorganic pyrophosphate (PPi) supersaturation in ageing and osteoarthritic cartilage. An allelic variant of the CILP gene has also been associated with lumbar disc disease.
CILP increases in early osteoarthrosis cartilage and may contribute to impaired matrix repair and PPi supersaturation in ageing joints.
CILP probably contributes to cartilage scaffolding and may modulate expression of cartilage matrix genes.
CILP suppresses IGF1-induced proliferation and IGF1R autophosphorylation, and may inhibit TGF-beta1 induction of matrix genes.
An allelic variant of the CILP gene has been associated with lumbar disc disease.
CILP is a secreted extracellular matrix protein that probably plays a role in cartilage scaffolding. It may antagonise TGF-beta1 and IGF1, suppressing IGF1-induced proliferation and proteoglycan synthesis and inhibiting IGF1R autophosphorylation. Overexpression may impair chondrocyte growth and matrix repair.
CILP is also known as CILP1 and HsT18872, and its HGNC name is cartilage intermediate layer protein. A previous name was nucleotide pyrophosphohydrolase, reflecting an early belief that the C-terminal region had NTPPHase activity, which later studies did not support.
CILP increases in early osteoarthrosis cartilage, and an allelic variant of the gene has been associated with lumbar disc disease. The mouse ortholog is Cilp. Check the datasheet of any product for its validated reactivity.
A related cartilage intermediate layer protein with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75339; product specifications from Assay Genie datasheets.