PALS2
PALS2 (protein associated with LIN7 2, MAGUK p55 family member) is a membrane-associated guanylate kinase that belongs to the p55-like subfamily of MAGUK proteins. It is also known as MPP6, VAM-1 and p55T, and is encoded by the PALS2 gene. Browse Assay Genie's current range of PALS2 research reagents below, or read on for the biology behind the target.
PALS2 is a member of the peripheral membrane-associated guanylate kinase (MAGUK) family. According to the NCBI Gene summary, MAGUK proteins function in tumour suppression and receptor clustering by forming multiprotein complexes. These complexes contain distinct sets of transmembrane, cytoskeletal and cytoplasmic signalling proteins, so MAGUKs act as scaffolds at the membrane. PALS2 is annotated as a membrane protein.
All MAGUKs share a PDZ-SH3-GUK core. The family is divided into four subfamilies according to size and the presence of additional domains: DLG-like, ZO1-like, p55-like and LIN2-like. PALS2, also called MPP6, belongs to the p55-like subfamily, whose prototype is MPP1. HGNC classifies it in the gene groups for membrane associated guanylate kinases, PDZ domain containing proteins and SH3 domain containing proteins. The human PALS2 gene has a mouse ortholog, Pals2. Researchers who study the PALS2 protein can therefore use it as a model of p55-like scaffold organisation.
The naming of this target reflects its history. Earlier names include membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) and membrane palmitoylated protein 6, and the symbols VAM-1, p55T and MPP6 are still found in the literature. The current HGNC name, protein associated with LIN7 2, reflects its relationship to the LIN7 proteins. The p55-like classification of MPP6 was described by Tseng et al. (2001). Anyone searching for a PALS2 antibody or PALS2 ELISA kit should keep these aliases in mind when comparing publications.
PALS2 is a p55-like MAGUK with a PDZ-SH3-GUK core, making it useful for studying how scaffold proteins assemble membrane complexes.
MAGUK proteins cluster receptors by forming multiprotein complexes, a process relevant to understanding PALS2 function at the membrane.
MAGUK family members are linked to tumour suppression, which places PALS2 within research on the proteins that organise growth-regulating signals.
MAGUKs link transmembrane, cytoskeletal and cytoplasmic signalling proteins, so PALS2 is relevant to work on how membrane signalling machinery is organised.
PALS2 is a p55-like MAGUK scaffold protein. MAGUK proteins form multiprotein complexes containing transmembrane, cytoskeletal and cytoplasmic signalling proteins, and the family is associated with receptor clustering and tumour suppression. PALS2 is annotated as a membrane protein with a PDZ-SH3-GUK core.
PALS2 is also known as MPP6, VAM-1 and p55T. Earlier names include membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) and membrane palmitoylated protein 6. Check which name a publication uses when comparing literature or reagent descriptions.
A mouse ortholog, Pals2, is listed for the human gene. The MAGUK family as a whole shares a PDZ-SH3-GUK core and is divided into four subfamilies, with PALS2 in the p55-like group. Check the datasheet of any product for its validated reactivity.
Other MAGUK family scaffold proteins and related membrane-complex targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NZW5; product specifications from Assay Genie datasheets.