SLC29A2
SLC29A2, also known as equilibrative nucleoside transporter 2 (ENT2, DER12, HNP36), is a member of the SLC29/ENT family of nucleoside transporters. The UniProt entry describes it as a nucleoside transporter protein for adenosine or thymidine transport, and it is studied in nucleoside uptake and adenosine signalling. Browse Assay Genie's current range of SLC29A2 research reagents below, or read on for the biology behind the target.
SLC29A2 is a nucleoside transporter. The uptake of nucleosides by transporters such as SLC29A2 is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in regulating many physiological processes through its effect on adenosine concentration at the cell surface. The UniProt annotation for this entry names adenosine and thymidine as the nucleosides concerned, and it also carries a cautionary note: the protein is described as non-functional and as not expressed on the cell membrane. Researchers should read that annotation alongside the wider literature on equilibrative nucleoside transport.
The SLC29A2 gene encodes equilibrative nucleoside transporter 2, which belongs to the SLC29A/ENT transporter (TC 2.A.57) family and to the HGNC group solute carrier family 29. UniProt lists its subcellular locations as the apical cell membrane, the basolateral cell membrane and the cell membrane in general, which is consistent with a role at the cell surface in moving nucleosides across the plasma membrane. The gene sits at 11q13.2 in humans. Orthologous genes, both named Slc29a2, are present in mouse and rat, so comparative work in rodent systems is possible.
The protein is known by several names. ENT2 is the commonly used short form, while DER12 and HNP36 are older aliases. The earlier HGNC name was solute carrier family 29 (equilibrative nucleoside transporter), member 2. Because the SLC29A2 protein is linked to both salvage-pathway nucleotide supply and extracellular adenosine levels, it is a point of interest for work on nucleotide metabolism and purinergic regulation.
Nucleoside uptake by transporters such as SLC29A2 supports nucleotide synthesis by salvage in cells that lack de novo biosynthetic pathways.
Nucleoside transport influences adenosine concentration at the cell surface, and so affects many physiological processes regulated by adenosine.
SLC29A2 is an SLC29/ENT family member with annotated apical and basolateral membrane locations, making it relevant to studies of polarised transport.
Mouse and rat both carry an Slc29a2 ortholog, allowing the human gene and its transport function to be examined in rodent models.
SLC29A2 is a nucleoside transporter for adenosine or thymidine. Nucleoside uptake supports salvage nucleotide synthesis and shapes adenosine concentration at the cell surface. Note that UniProt also annotates this entry as non-functional and not expressed on the cell membrane.
SLC29A2 is also called equilibrative nucleoside transporter 2 (ENT2), with DER12 and HNP36 as aliases. Its earlier HGNC name was solute carrier family 29 (equilibrative nucleoside transporter), member 2. It belongs to the SLC29/ENT family.
Yes. Both mouse and rat have an ortholog named Slc29a2, so the gene can be studied in rodent systems. Cross-species work should be planned with care; check the datasheet of any product for its validated reactivity.
Other solute carrier transporters, including family members involved in membrane transport of metabolites, ions and neurotransmitters.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14542; product specifications from Assay Genie datasheets.