ITGA3
ITGA3 (integrin subunit alpha 3, also known as CD49c, VLA3a, VCA-2, GAP-B3 and MSK18) is an integrin alpha chain that acts as a cell surface adhesion molecule. It pairs with the beta 1 subunit to form an integrin that interacts with extracellular matrix proteins, including laminins. Browse Assay Genie's current range of ITGA3 research reagents below, or read on for the biology behind the target.
ITGA3 is a member of the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins made up of an alpha chain and a beta chain, and they function as cell surface adhesion molecules. The ITGA3 subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins, including members of the laminin family.
The ITGA3 gene encodes a preproprotein that is proteolytically processed into light and heavy chains, which together make up the alpha 3 subunit. According to UniProt, the protein is found at the cell membrane, including the membranes of invadopodia and filopodia. The HGNC classifies it within the CD molecules and the integrin alpha subunit gene groups, and the mouse ortholog is Itga3.
ITGA3 has been known by several names, including CD49c, VLA3a, VCA-2, GAP-B3 and MSK18. Earlier gene names were antigen identified by monoclonal antibody J143, and integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor). Expression of the gene may be correlated with breast cancer metastasis. In a microbial infection context, the ITGA3:ITGB1 integrin may act as a receptor for R. delemar CotH7 in alveolar epithelial cells, which may be an early step in the progression of pulmonary mucormycosis.
As an integrin alpha chain, ITGA3 contributes to cell surface adhesion and is studied for its interactions with extracellular matrix proteins.
Paired with the beta 1 subunit, ITGA3 forms an integrin that interacts with laminin family members, making it relevant to matrix-binding studies.
ITGA3 expression may be correlated with breast cancer metastasis, which makes it a candidate in cancer progression research.
The ITGA3:ITGB1 integrin may act as a receptor for R. delemar CotH7 on alveolar epithelial cells, relevant to early pulmonary mucormycosis.
ITGA3 is an integrin alpha chain that works as a cell surface adhesion molecule. It pairs with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins, including members of the laminin family. It is located at the cell membrane, including invadopodia and filopodia.
ITGA3, integrin subunit alpha 3, is also called CD49c, VLA3a, VCA-2, GAP-B3 and MSK18. UniProt lists the protein as integrin alpha-3. Earlier names include antigen identified by monoclonal antibody J143, and alpha 3 subunit of the VLA-3 receptor. The preproprotein is processed into light and heavy chains.
The NCBI Gene summary notes that ITGA3 expression may be correlated with breast cancer metastasis. UniProt also reports that the ITGA3:ITGB1 integrin may act as a receptor for R. delemar CotH7 in alveolar epithelial cells, possibly an early step in pulmonary mucormycosis. A mouse ortholog, Itga3, exists; check the datasheet of any product for its validated reactivity.
Other integrin alpha subunits and related cell adhesion targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P26006; product specifications from Assay Genie datasheets.