ARSB
ARSB (arylsulfatase B, also known as ASB) is a lysosomal sulfatase that removes sulfate groups from chondroitin-4-sulfate and regulates its degradation. It belongs to the sulfatase family, and deficiency of the enzyme causes mucopolysaccharidosis type VI. Browse Assay Genie's current range of ARSB research reagents below, or read on for the biology behind the target.
ARSB is a sulfatase that removes sulfate groups from chondroitin-4-sulfate (C4S) and so regulates its degradation. According to the NCBI Gene summary, the arylsulfatase B homodimer hydrolyses sulfate groups of N-acetyl-D-galactosamine, chondroitin sulfate and dermatan sulfate. The enzyme is classified as EC 3.1.6.12 and is targeted to the lysosome, although UniProt also records it at the cell surface.
Beyond lysosomal turnover of glycosaminoglycans, UniProt annotates roles for ARSB in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system it is described as a regulator of neurite outgrowth and neuronal plasticity, acting through control of sulfate glycosaminoglycan and neurocan levels. The ARSB gene is a member of the HGNC sulfatases gene group, and the ARSB protein belongs to the sulfatase family. The mouse and rat orthologs are both named Arsb.
Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for the gene. ARSB is also known by the alias ASB, and these names appear in the literature on sulfatases, glycosaminoglycan catabolism and lysosomal storage disease.
ARSB deficiency results in mucopolysaccharidosis type VI, an autosomal recessive lysosomal storage disorder, making the enzyme central to studies of this condition.
ARSB hydrolyses sulfate groups from chondroitin sulfate, dermatan sulfate and N-acetyl-D-galactosamine, and regulates degradation of chondroitin-4-sulfate.
In the central nervous system ARSB regulates neurite outgrowth and neuronal plasticity by controlling sulfate glycosaminoglycans and neurocan levels.
ARSB is involved in regulating cell adhesion, migration and invasion in colonic epithelium, linking sulfatase activity to epithelial cell behaviour.
ARSB removes sulfate groups from chondroitin-4-sulfate and regulates its degradation. It also hydrolyses sulfate groups of N-acetyl-D-galactosamine and dermatan sulfate. UniProt additionally describes roles in colonic epithelial cell adhesion, migration and invasion, and in neurite outgrowth and neuronal plasticity in the central nervous system.
ARSB stands for arylsulfatase B, and ASB is the listed alias. The enzyme carries the EC number 3.1.6.12. According to the NCBI Gene summary, two alternatively spliced transcript variants encoding distinct isoforms have been found for the gene.
Deficiency of arylsulfatase B causes mucopolysaccharidosis type VI, an autosomal recessive lysosomal storage disorder. Orthologs exist in mouse and rat, both named Arsb. Check the datasheet of any product for its validated reactivity.
Other sulfatases, lysosomal enzymes and glycosaminoglycan-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P15848; product specifications from Assay Genie datasheets.