MIA2
MIA2 (MIA SH3 domain ER export factor 2) is an endoplasmic reticulum membrane protein that helps export cargo too large for standard COPII vesicles. It is also known as TALI, MEA6, CTAGE5 and cTAGE-5, among other aliases. Browse Assay Genie's current range of MIA2 research reagents below, or read on for the biology behind the target.
MIA2 acts in the early secretory pathway. It plays a role in transporting cargos that are too large to fit into COPII-coated vesicles. These cargos need specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. NCBI Gene describes the encoded protein as a receptor in the endoplasmic reticulum that supports export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs).
Through its role in exporting lipoprotein particles, MIA2 may contribute to cholesterol and triglyceride homeostasis. It is also required for secretion of collagen VII (COL7A1). It loads COL7A1 into transport carriers and recruits PREB/SEC12 at the endoplasmic reticulum exit sites. The protein belongs to the MIA/OTOR family, and HGNC places the MIA2 gene in the CTAGE, MIA and SH3 domain containing groups.
The gene has a complex naming history, reflected in its aliases. Three major classes of transcripts are generated: melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts, and transcripts that include exons from both, known as TANGO1-like or TALI. Alternative splicing within these classes gives multiple transcript variants and isoforms. Previous names include CTAGE family member 5, meningioma expressed antigen 6 and melanoma inhibitory activity 2. A mouse ortholog, Mia2, is recorded. Researchers studying MIA2 using an antibody, ELISA kit or recombinant protein should note this transcript and isoform diversity when interpreting results.
MIA2 is involved in exporting cargos too large for COPII-coated vesicles, making it relevant to studies of endoplasmic reticulum exit sites.
It participates in export of pre-chylomicrons and pre-VLDLs from the endoplasmic reticulum, linking it to lipoprotein assembly and secretion.
By supporting lipoprotein export, MIA2 may play a role in cholesterol and triglyceride homeostasis.
MIA2 is required for COL7A1 secretion, loading it into transport carriers and recruiting PREB/SEC12 at exit sites.
MIA2 is an endoplasmic reticulum membrane protein that supports export of cargos too large for COPII-coated vesicles. It participates in export of pre-chylomicrons and pre-VLDLs, may influence cholesterol and triglyceride homeostasis, and is required for collagen VII secretion by loading COL7A1 into transport carriers.
The gene produces three major transcript classes: MIA2-specific, cTAGE family member 5-specific (CTAGE5), and hybrid transcripts called TANGO1-like or TALI. Alternative splicing adds further variants and isoforms. This explains aliases such as TALI, MEA6, MGEA11 and cTAGE-5A to D.
A mouse ortholog, Mia2, is recorded for the human gene. MIA2 belongs to the MIA/OTOR family, which also includes MIA. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other MIA family members and related endoplasmic reticulum export targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96PC5; product specifications from Assay Genie datasheets.