The Caveolin-2 Monoclonal Antibody (CAB4890) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbit monoclonal technology, offers high specificity and sensitivity for detecting Caveolin-2 in a variety of experimental settings.Caveolin-2, a key component of caveolae, plays a crucial role in the regulation of cell signaling pathways and membrane organization. By targeting Caveolin-2, researchers can gain valuable insights into its functions and implications in various biological processes.
This antibody is validated for use in WB, IHC-P, IP, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
Caveolin-2 Monoclonal Antibody
SKU:
CAB4890
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Clone Number:
ARC0323
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).
Purification Method
Affinity purification
Gene ID
858
RRID
AB_2863375
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Mouse lung, using Caveolin-2 Rabbit mAb (CAB4890) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Western blot analysis of lysates from 293T cells, using Caveolin-2 Rabbit mAb (CAB4890) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Immunoprecipitation analysis of 300 μg extracts of HeLa cells using 3 μg Caveolin-2 antibody (CAB4890). Western blot was performed from the immunoprecipitate using Caveolin-2 antibody (CAB4890) at a dilution of 1:1000.
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