The Caveolin-3 Monoclonal Antibody (CAB4891) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is produced using rabbit monoclonal technology, ensuring high specificity and sensitivity in detecting Caveolin-3 in human samples.Caveolin-3 is a key structural component of caveolae, small invaginations in the plasma membrane that play essential roles in signaling, lipid metabolism, and protein trafficking. Dysregulation of Caveolin-3 has been implicated in various diseases, including muscular dystrophies and cardiovascular disorders.
This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Caveolin-3 Monoclonal Antibody
SKU:
CAB4891
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC2473
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Purification Method
Affinity purification
Gene ID
859
RRID
AB_2863376
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using Caveolin-3 Rabbit mAb (CAB4891) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
Immunohistochemistry analysis of paraffin-embedded Rat heart using Caveolin-3 Rabbit mAb (CAB4891) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
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