SHANK1 Antibody [N22/21 (Formerly sold as S22-21)]
SHANK1 Antibody [N22/21 (Formerly sold as S22-21)] is a mouse monoclonal antibody directed against SHANK1, offered by Assay Genie for research applications. Reported applications include WB, IHC and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
SHANK1 is a postsynaptic density (PSD) scaffolding protein that integrates neurotransmitter receptors and signaling molecules into the cortical cytoskeleton. It plays a key role in synaptic organization, plasticity, and signal transduction at excitatory synapses. SHANK1 recruits proteins such as betaPIX and PAK to dendritic spines, regulating spine morphology and synaptic strength. It also interacts with ionotropic and metabotropic glutamate receptor complexes, contributing to synaptic signaling fidelity. Alternative splicing of SHANK1 influences its interaction network, affecting synaptic composition during development and in the adult brain. Altered SHANK1 expression or function has been linked to cognitive deficits and neuropsychiatric conditions, highlighting its relevance in neurodegenerative disease mechanisms. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SHANK1 Antibody [N22/21 (Formerly sold as S22-21)]
1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 2. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242. 3. Gong Y., et al. (2009) Brain Res. 1292: 191-198.
