TRPV3 Antibody [N15/4 (Formerly sold as S15-4)] is a mouse monoclonal antibody directed against TRPV3, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein G.
Transient Receptor Potential Vanilloid 3 (TRPV3) is a non-selective cation channel belonging to the thermosensitive TRP channel family, which plays a critical role in sensory physiology and cellular signaling. Activated by warm temperatures ranging from 22°C to 40°C, TRPV3 is predominantly expressed in keratinocytes and subsets of sensory neurons that innervate the skin. It contributes to temperature sensation, skin barrier function, and vasoregulation. Located on chromosome 17 near the TRPV1 gene, TRPV3 can form heteromeric complexes with other TRP channels, potentially modulating its biophysical properties and expanding its functional repertoire. While traditionally studied in the context of peripheral sensory biology, TRPV3 is increasingly recognized for its relevance in the central nervous system. Emerging evidence suggests that TRPV3 may influence neuroinflammatory pathways, glial activation, and neuronal excitability—processes intimately linked to the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Aberrant TRPV3 activity has been associated with altered calcium homeostasis and oxidative stress, both of which are key contributors to neuronal dysfunction and degeneration. As a modulator of both peripheral and central signaling, TRPV3 represents a promising target for therapeutic intervention in neurodegenerative disorders. Ongoing research into its expression patterns, regulatory mechanisms, and interaction networks is shedding new light on its potential role in maintaining neuronal health and resilience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
TRPV3 Antibody [N15/4 (Formerly sold as S15-4)]
Product SKU:
STMA00090
Size:
100 µg
Target:
TRPV3
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N15/4 (Formerly sold as S15-4)
Research Areas:
Neuroscience, Ion Channels, Transient Receptor Potential (TRP) Channels
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP, AM
Antibody Isotype:
IgG2a
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~90kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide amino acids 774-791 (C-terminus) of rat TrpV3
