Anti-SHANK1/SHANK3 Antibody [N367/51 (Formerly sold as S367-51)]

SHANK1/SHANK3 Antibody [N367/51 (Formerly sold as S367-51)]

SHANK1/SHANK3 Antibody [N367/51 (Formerly sold as S367-51)] is a mouse monoclonal antibody directed against SHANK1/SHANK3, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein G.

SHANK1 and SHANK3 are critical scaffolding proteins within the postsynaptic density (PSD), where they orchestrate the assembly of multiprotein complexes essential for synaptic signaling and plasticity. As members of the SHANK/ProSAP family, these proteins anchor neurotransmitter receptors—both ionotropic and metabotropic—to the cortical actin cytoskeleton, thereby stabilizing synaptic architecture and function. SHANK proteins play a pivotal role in recruiting key signaling molecules such as βPIX and PAK to dendritic spines, modulating spine morphology and synaptic strength. Their interactions with glutamate receptor complexes position them as central regulators of excitatory synaptic transmission. Importantly, alternative splicing of SHANK transcripts diversifies their interaction networks across developmental stages and brain regions. This molecular versatility is essential for normal neurodevelopment and synaptic maturation. Emerging evidence links SHANK1 and SHANK3 dysregulation to a spectrum of neurodevelopmental and neurodegenerative disorders, including autism spectrum disorder (ASD), schizophrenia, and Alzheimer’s disease. Their involvement in synaptic integrity and plasticity makes them promising targets for therapeutic intervention and biomarkers for early disease detection. Understanding SHANK1/3 function is therefore crucial for advancing neuroscience and developing strategies to combat synaptic dysfunction in brain disorders. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.