CavBeta2 Antibody [N8b/1 (Formerly sold as S8B-1)]
CavBeta2 Antibody [N8b/1 (Formerly sold as S8B-1)] is a mouse monoclonal antibody directed against CavBeta2, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
The Cav Beta 2 subunit is a critical auxiliary component of voltage-gated calcium channels (VGCCs), playing a central role in neuronal excitability and synaptic signaling. It facilitates the trafficking of the pore-forming alpha1 subunit to the plasma membrane by masking an endoplasmic reticulum (ER) retention signal, ensuring proper channel localization and surface expression. This process is essential for the functional assembly of VGCCs at the neuronal membrane. Beyond trafficking, Cav Beta 2 directly influences the biophysical properties of calcium channels, including voltage sensitivity, activation kinetics, and inactivation dynamics. These properties are crucial for regulating calcium influx, which in turn governs neurotransmitter release, gene expression, and neuronal survival. Dysregulation of Cav Beta 2 function has been implicated in several neurodegenerative diseases, where altered calcium homeostasis contributes to synaptic dysfunction, excitotoxicity, and progressive neuronal loss. Understanding the molecular mechanisms by which Cav Beta 2 modulates VGCCs offers valuable insights into the pathophysiology of disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). As a modulator of both channel trafficking and function, Cav Beta 2 represents a promising target for therapeutic intervention aimed at restoring calcium signaling balance in neurodegenerative conditions. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
CavBeta2 Antibody [N8b/1 (Formerly sold as S8B-1)]
Product SKU:
STMA00095
Size:
100 µg
Target:
CavBeta2
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N8b/1 (Formerly sold as S8B-1)
Research Areas:
Neuroscience, Ion Channels, Calcium Channels, Voltage-Gated Calcium Channels
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP, AM
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide amino acids 189-205 of rat CavBeta2
