Anti-GABAB Receptor 1 Antibody [N93A/49 (Formerly sold as S93A-49)]

GABAB Receptor 1 Antibody [N93A/49 (Formerly sold as S93A-49)]

GABAB Receptor 1 Antibody [N93A/49 (Formerly sold as S93A-49)] is a mouse monoclonal antibody directed against GABAB Receptor 1, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.

GABA (γ-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter, acting through three receptor types: GABA-A, GABA-B, and GABA-C. While GABA-A and GABA-C receptors are ionotropic and mediate fast synaptic inhibition, GABA-B receptors are metabotropic, G protein-coupled receptors that regulate slow, prolonged inhibitory signaling. The functional GABA-B receptor is a heterodimer composed of GABA-B Receptor 1 (GABBR1), which binds the ligand, and GABA-B Receptor 2 (GABBR2), which couples to intracellular G proteins. GABBR1 exists in two isoforms—GABBR1a and GABBR1b—each contributing to distinct signaling dynamics. Upon activation, GABA-B receptors inhibit adenylate cyclase, reduce calcium influx at presynaptic terminals, and activate inwardly rectifying potassium channels postsynaptically, thereby modulating neurotransmitter release and neuronal excitability. GABBR1 plays a critical role in maintaining synaptic balance and has been implicated in key neurological processes such as hippocampal long-term potentiation, slow-wave sleep, and motor control. Importantly, dysregulation of GABA-B signaling—particularly involving GABBR1—has been linked to neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Altered GABBR1 expression or function may contribute to excitotoxicity, impaired synaptic plasticity, and cognitive decline. As a result, GABBR1 is emerging as a promising therapeutic target and biomarker in neurodegeneration research, offering new avenues for modulating inhibitory tone and preserving neural function in aging and disease. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.