Anti-NrCAM Antibody [N364/51 (Formerly sold as S364-51)]

NrCAM Antibody [N364/51 (Formerly sold as S364-51)]

NrCAM Antibody [N364/51 (Formerly sold as S364-51)] is a mouse monoclonal antibody directed against NrCAM, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein G.

Neuronal Cell Adhesion Molecule (NrCAM) is a member of the immunoglobulin superfamily involved in axon guidance, synaptic stability, and neural circuit formation. It contains six Ig-like domains, five fibronectin type III repeats, and an intracellular domain that interacts with cytoskeletal and signaling proteins. NrCAM is expressed in the brain, spinal cord, and peripheral nervous system, where it mediates cell-cell interactions critical for axon pathfinding and synaptic targeting. It serves as a ligand for axonin-1 and F3/contactin, influencing growth cone motility and axon crossing at the midline. In neurodegenerative disease research, NrCAM has been linked to synaptic disassembly, neuroinflammation, and glioma progression. Its interaction with ankyrin-G and voltage-gated sodium channels at the node of Ranvier suggests a role in maintaining neuronal excitability and conduction. Dysregulation of NrCAM expression has been observed in Alzheimer’s disease and high-grade gliomas, highlighting its dual role in neurodevelopment and pathology. NrCAM is also implicated in neuropsychiatric conditions such as autism and schizophrenia, making it a potential biomarker and therapeutic target for disorders involving synaptic dysfunction and neural connectivity. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.