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Anti-SEMA3C Antibody (CAB15386)

SKU:
CAB15386
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-SEMA3C Antibody CAB15386
  • Developmental Biology Anti-SEMA3C Antibody CAB15386
€139 - €419
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Description

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Antibody Name:Anti-SEMA3C Antibody
Antibody SKU:CAB15386
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-330 of human SEMA3C (NP_006370.1).
Application:WB IF
Recommended Dilution:WB 1:200 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse small intestine, Rat small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-330 of human SEMA3C (NP_006370.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GSSQ PQAR VYLT FDEL RETK TSEY FSLS HHPL DYRI LLMD EDQD RIYV GSKD HILS LNIN NISQ EALS VFWP ASTI KVEE CKMA GKDP THGC GNFV RVIQ TFNR THLY VCGS GAFS PVCT YLNR GRRS EDQV FMID SKCE SGKG RCSF NPNV NTVS VMIN EELF SGMY IDFM GTDA AIFR SLTK RNAV RTDQ HNSK WLSE PMFV DAHV IPDG TDPN DAKV YFFF KEKL TDNN RSTK QIHS MIAR ICPN DTGG LRSL VNKW TTFL KARL VCSV TDED GPET HFDE LEDV FLLE TDNP RTTL VYGI FTTS SS
Gene ID:10512
Uniprot:Q99985
Cellular Location:Secreted
Calculated MW:26kDa/85kDa
Observed MW:85kDa
Synonyms:SEMA3C, SEMAE, SemE
Background:
UniProt Protein Function:SEMA3C: a secreted protein that may be involved in cell survival mechanisms. Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain. Binds with high affinity to the receptor NRP2.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q21-q31

Cellular Component: extracellular space; membrane

Molecular Function:receptor activity; semaphorin receptor binding

Biological Process: neural tube development; response to drug; axon guidance; limb bud formation; somitogenesis; blood vessel remodeling; immune response; neural crest cell migration; post-embryonic development

NCBI Summary:This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
UniProt Code:Q99985
NCBI GenInfo Identifier:8134685
NCBI Gene ID:10512
NCBI Accession:Q99985.2
UniProt Related Accession:Q99985
Molecular Weight:~ 85kDa
NCBI Full Name:Semaphorin-3C
NCBI Synonym Full Names:semaphorin 3C
NCBI Official Symbol:SEMA3C  
NCBI Official Synonym Symbols:SemE; SEMAE  
NCBI Protein Information:semaphorin-3C
UniProt Protein Name:Semaphorin-3C
UniProt Synonym Protein Names:Semaphorin-E; Sema E
Protein Family:Semaphorin
UniProt Gene Name:SEMA3C  
UniProt Entry Name:SEM3C_HUMAN
Anti-SEMA3C Antibody (CAB15386)Western blot analysis of extracts of various cell lines, using SEMA3C antibody (CAB15386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-SEMA3C Antibody (CAB15386)Immunofluorescence analysis of L929 cells using SEMA3C antibody (CAB15386) at dilution of 1:100. Blue: DAPI for nuclear staining.

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