Anti-CEACAM7 Antibody (CAB8112)

Antibody Name:	CEACAM7 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8112
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 36-242 of human CEACAM7 (NP_008821.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	MCF7, Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 36-242 of human CEACAM7 (NP_008821.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TNID VVPF NVAE GKEV LLVV HNES QNLY GYNW YKGE RVHA NYRI IGYV KNIS QENA PGPA HNGR ETIY PNGT LLIQ NVTH NDAG IYTL HVIK ENLV NEEV TRQF YVFS EPPK PSIT SNNF NPVE NKDI VVLT CQPE TQNT TYLW WVNN QSLL VSPR LLLS TDNR TLVL LSAT KNDI GPYE CEIQ NPVG ASRS DPVT LNVR YESV QAS
Gene ID:	1087
Uniprot:	Q14002
Cellular Location:	Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:	19kDa/29kDa
Observed MW:	29kDa

Synonyms:

CEACAM7, CGM2

Background:

This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	CEACAM7: Belongs to the immunoglobulin superfamily. CEA family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, GPI anchor; Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane; integral to membrane
NCBI Summary:	This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Code:	Q14002
NCBI GenInfo Identifier:	5901930
NCBI Gene ID:	1087
NCBI Accession:	NP_008821.1
UniProt Secondary Accession:	Q14002,O15148, O15149, Q0VAC1, Q13983, Q9UPJ2, A8K848
UniProt Related Accession:	Q14002
Molecular Weight:	19,031 Da
NCBI Full Name:	carcinoembryonic antigen-related cell adhesion molecule 7
NCBI Synonym Full Names:	carcinoembryonic antigen related cell adhesion molecule 7
NCBI Official Symbol:	CEACAM7
NCBI Official Synonym Symbols:	CGM2
NCBI Protein Information:	carcinoembryonic antigen-related cell adhesion molecule 7
UniProt Protein Name:	Carcinoembryonic antigen-related cell adhesion molecule 7
UniProt Synonym Protein Names:	Carcinoembryonic antigen CGM2
Protein Family:	Carcinoembryonic antigen-related cell adhesion molecule
UniProt Gene Name:	CEACAM7
UniProt Entry Name:	CEAM7_HUMAN

	Western blot analysis of extracts of various cell lines, using CEACAM7 antibody (CAB8112) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human liver cancer using CEACAM7 antibody (CAB8112) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse kidney using CEACAM7 antibody (CAB8112) at dilution of 1:100 (40x lens).

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)