Description
Meis1 Transcription Factor Activity Assay
The MEIS1 Transcription Factor Activity Assay Kit is a powerful tool designed for the precise measurement of MEIS1 transcription factor activity in a variety of samples, including cell lysates and tissue extracts. This kit offers exceptional sensitivity and specificity, ensuring consistent and accurate results for a range of research applications.MEIS1 is a key transcription factor that plays a critical role in the regulation of gene expression, cell differentiation, and development. Dysregulation of MEIS1 activity has been implicated in various diseases, including cancer, developmental disorders, and cardiovascular diseases, highlighting its importance as a potential therapeutic target.
With the MEIS1 Transcription Factor Activity Assay Kit, researchers can gain valuable insights into the molecular mechanisms underlying various diseases and explore new opportunities for targeted therapeutic interventions. Don't miss out on this essential tool for your research studies.
| Product Name: | Meis1 Transcription Factor Activity Assay |
| Product Code: | TFAB00133 |
| Target: | Meis1 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Meis1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2p14 Molecular Function:protein binding Biological Process: negative regulation of myeloid cell differentiation Disease: Restless Legs Syndrome, Susceptibility To, 7 |
| NCBI Summary: | Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00470 |
| NCBI GenInfo Identifier: | 3024112 |
| NCBI Gene ID: | 4211 |
| NCBI Accession: | O00470.1 |
| UniProt Secondary Accession: | O00470,A8MV50, |
| UniProt Related Accession: | O00470 |
| Molecular Weight: | 50,576 Da |
| NCBI Full Name: | Homeobox protein Meis1 |
| NCBI Synonym Full Names: | Meis homeobox 1 |
| NCBI Official Symbol: | MEIS1 |
| NCBI Protein Information: | homeobox protein Meis1 |
| UniProt Protein Name: | Homeobox protein Meis1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | MEIS1 |
