UniProt Protein Function: | Oct8: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). Belongs to the POU transcription factor family. Class- 3 subfamily.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 2q12.1Cellular Component: nucleusMolecular Function: sequence-specific DNA bindingBiological Process: central nervous system development; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015] |
UniProt Code: | P20264 |
NCBI GenInfo Identifier: | 2506534 |
NCBI Gene ID: | 5455 |
NCBI Accession: | P20264.2 |
UniProt Secondary Accession: | P20264,P78379, Q4ZG25 |
UniProt Related Accession: | P20264 |
Molecular Weight: | 50,327 Da |
NCBI Full Name: | POU domain, class 3, transcription factor 3 |
NCBI Synonym Full Names: | POU class 3 homeobox 3 |
NCBI Official Symbol: | POU3F3Â Â |
NCBI Official Synonym Symbols: | BRN1; OTF8; oct-8; brain-1Â Â |
NCBI Protein Information: | POU domain, class 3, transcription factor 3 |
UniProt Protein Name: | POU domain, class 3, transcription factor 3 |
UniProt Synonym Protein Names: | Brain-specific homeobox/POU domain protein 1; Brain-1; Brn-1; Octamer-binding protein 8; Oct-8; Octamer-binding transcription factor 8; OTF-8 |
Protein Family: | POU domain, class 3, transcription factor |
UniProt Gene Name: | POU3F3Â Â |
UniProt Entry Name: | PO3F3_HUMAN |