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Anti-MRE11A Antibody (CAB2559)

SKU:
CAB2559
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-MRE11A Antibody CAB2559
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-MRE11A Antibody CAB2559
€139 - €419
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Description

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Antibody Name:Anti-MRE11A Antibody
Antibody SKU:CAB2559
Antibody Size:20uL, 50uL, 100uL
Application:WB IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human MRE11A (NP_005581.2).
Application:WB IF IP
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, SW480, U-937, A-549, A-375, Mouse liver, Mouse heart, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human MRE11A (NP_005581.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSTA DALD DENT FKIL VATD IHLG FMEK DAVR GNDT FVTL DEIL RLAQ ENEV DFIL LGGD LFHE NKPS RKTL HTCL ELLR KYCM GDRP VQFE ILSD QSVN FGFS KFPW VNYQ DGNL NISI PVFS IHGN HDDP TGAD ALCA LDIL SCAG FVNH FGRS MSVE KIDI SPVL LQKG STKI ALYG LGSI PDER LYRM FVNK KVTM LRPK E
Gene ID:4361
Uniprot:P49959
Cellular Location:Nucleus
Calculated MW:77kDa/80kDa/81kDa
Observed MW:90kDa-100kDa
Synonyms:MRE11, ATLD, HNGS1, MRE11A, MRE11B
Background:This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
UniProt Protein Function:MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
UniProt Protein Details:

Protein type:DNA-binding; Cell cycle regulation; DNA repair, damage; Deoxyribonuclease

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: nucleoplasm; chromosome, telomeric region; Mre11 complex; cytosol; nucleus; chromatin

Molecular Function:protein C-terminus binding; ATP-dependent DNA helicase activity; protein binding; nuclease activity; DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; manganese ion binding; endonuclease activity; double-stranded DNA binding; 3'-5' exonuclease activity; endodeoxyribonuclease activity

Biological Process: positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; telomere maintenance via telomerase; DNA repair; regulation of mitotic recombination; DNA catabolic process, endonucleolytic; positive regulation of protein amino acid autophosphorylation; DNA duplex unwinding; double-strand break repair via nonhomologous end joining; double-strand break repair via homologous recombination; DNA recombination; cell proliferation; intra-S DNA damage checkpoint; base-excision repair; nucleotide-excision repair; meiotic recombination; double-strand break repair; mitotic cell cycle G2/M transition DNA damage checkpoint; synapsis; positive regulation of interferon type I production; innate immune response; telomere maintenance; response to DNA damage stimulus

Disease: Ataxia-telangiectasia-like Disorder 1

NCBI Summary:This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P49959
NCBI GenInfo Identifier:17380137
NCBI Gene ID:4361
NCBI Accession:P49959.3
UniProt Secondary Accession:P49959,O43475, B3KTC7,
UniProt Related Accession:P49959
Molecular Weight:708
NCBI Full Name:Double-strand break repair protein MRE11A
NCBI Synonym Full Names:MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NCBI Official Symbol:MRE11A  
NCBI Official Synonym Symbols:ATLD; HNGS1; MRE11; MRE11B  
NCBI Protein Information:double-strand break repair protein MRE11A; AT-like disease; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; DNA recombination and repair protein
UniProt Protein Name:Double-strand break repair protein MRE11A
UniProt Synonym Protein Names:Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
Protein Family:Double-strand break repair protein
UniProt Gene Name:MRE11A  
UniProt Entry Name:MRE11_HUMAN
Anti-MRE11A Antibody (CAB2559)Western blot analysis of extracts of various cell lines, using MRE11A antibody (CAB2559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-MRE11A Antibody (CAB2559)Immunoprecipitation analysis of 200ug extracts of A-549 cells, using 3 ug MRE11A antibody (CAB2559). Western blot was performed from the immunoprecipitate using MRE11A antibody (CAB2559) at a dilition of 1:1000.

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