Description
ETS1 (Phospho-Thr38)Transcription Factor Activity Assay
The ETS1 Phospho-Thr38 Transcription Factor Activity Assay is a cutting-edge tool for measuring the activity of ETS1, a key transcription factor involved in regulating gene expression. This assay provides researchers with the ability to accurately quantify the phosphorylation status of ETS1 at threonine 38, allowing for a deeper understanding of its role in various cellular processes.With its high sensitivity and specificity, the ETS1 Phospho-Thr38 Transcription Factor Activity Assay delivers reliable and reproducible results, making it an indispensable tool for studying transcriptional regulation, signal transduction, and cell differentiation.
By accurately measuring ETS1 phosphorylation, researchers can gain valuable insights into the molecular mechanisms underlying disease states such as cancer, inflammation, and autoimmune disorders.Overall, the ETS1 Phospho-Thr38 Transcription Factor Activity Assay offers a comprehensive solution for investigating the functional significance of ETS1 in cellular pathways, making it a valuable resource for both basic research and drug discovery efforts.
| Product Name: | ETS1 (Phospho-Thr38)Transcription Factor Activity Assay |
| Product Code: | TFAB00025 |
| Target: | ETS1 (Phospho-Thr38) |
| Synonyms: | p54 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie ETS1 (Phospho-Thr38) transcription factor activity assay allows for the detection and qualitative analysis of ETS1 (Phospho-Thr38) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; identical protein binding; protein binding; transcription factor activity Biological Process: cell motility involved in cell locomotion; immune response; negative regulation of cell proliferation; PML body organization and biogenesis; positive regulation of cell motility; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of angiogenesis |
| NCBI Summary: | This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P14921 |
| NCBI GenInfo Identifier: | 119641 |
| NCBI Gene ID: | 2113 |
| NCBI Accession: | P14921.1 |
| UniProt Secondary Accession: | P14921,Q14278, Q16080, Q6N087, Q96AC5, A9UL17, F5GYX9 |
| UniProt Related Accession: | P14921 |
| Molecular Weight: | 30,860 Da |
| NCBI Full Name: | Protein C-ets-1 |
| NCBI Synonym Full Names: | ETS proto-oncogene 1, transcription factor |
| NCBI Official Symbol: | ETS1 |
| NCBI Official Synonym Symbols: | p54; ETS-1; EWSR2; c-ets-1 |
| NCBI Protein Information: | protein C-ets-1 |
| UniProt Protein Name: | Protein C-ets-1 |
| UniProt Synonym Protein Names: | p54 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS1 |
| UniProt Entry Name: | ETS1_HUMAN |
