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Anti-TCL1A Antibody (CAB0629)

SKU:
CAB0629
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-TCL1A Antibody CAB0629
  • Cell Biology Antibodies 1 Anti-TCL1A Antibody CAB0629
€139 - €419
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Description

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Antibody Name:Anti-TCL1A Antibody
Antibody SKU:CAB0629
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:Human
Positive Samples:Ramos
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAEC PTLG EAVT DHPD RLWA WEKF VYLD EKQH AWLP LTIE IKDR LQLR VLLR REDV VLGR PMTP TQIG PSLL PIMW QLYP DGRY RSSD SSFW RLVY HIKI DGVE DMLL ELLP DD
Gene ID:8115
Uniprot:P56279
Cellular Location:Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus
Calculated MW:13kDa
Observed MW:16kDa
Synonyms:TCL1A, TCL1
Background:
UniProt Protein Function:TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family.
UniProt Protein Details:

Protein type:Oncoprotein; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum; pronucleus; cell cortex

Molecular Function:protein binding

Biological Process: multicellular organismal development; stem cell maintenance

NCBI Summary:Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
UniProt Code:P56279
NCBI GenInfo Identifier:3024699
NCBI Gene ID:8115
NCBI Accession:P56279.1
UniProt Related Accession:P56279
Molecular Weight:
NCBI Full Name:T-cell leukemia/lymphoma protein 1A
NCBI Synonym Full Names:TCL1 family AKT coactivator A
NCBI Official Symbol:TCL1A  
NCBI Official Synonym Symbols:TCL1  
NCBI Protein Information:T-cell leukemia/lymphoma protein 1A
UniProt Protein Name:T-cell leukemia/lymphoma protein 1A
UniProt Synonym Protein Names:Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1
Protein Family:MYB-like transcription factor
UniProt Gene Name:TCL1A  
UniProt Entry Name:TCL1A_HUMAN
Anti-TCL1A Antibody (CAB0629)Western blot analysis of extracts of Ramos cells, using TCL1A antibody (CAB0629) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-TCL1A Antibody (CAB0629)Immunofluorescence analysis of U2OS cells using TCL1A antibody (CAB0629). Blue: DAPI for nuclear staining.

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