Description

Biotin Anti-Human CD58 Antibody [TS2/9.1]

The Human CD58 Monoclonal Antibody (Biotin Conjugated, TS2/9.1) is a highly specific tool for research involving CD58, a cell surface protein with key roles in immune responses and cell adhesion. This monoclonal antibody, conjugated with biotin for convenient detection and analysis, is derived from the TS2/9.1 hybridoma cell line. CD58, also known as LFA-3, is a critical molecule in immune recognition and T-cell activation. Its interaction with the CD2 receptor on T cells plays a crucial role in immune synapse formation and T cell-mediated immune responses. The Human CD58 Monoclonal Antibody (Biotin Conjugated, TS2/9.1) is validated for use in various immunological applications, such as flow cytometry, immunofluorescence, and ELISA, enabling precise detection and quantification of CD58 expression in human samples.

Studying the function and regulation of CD58 is essential for understanding immune cell interactions, inflammatory responses, and autoimmune diseases. The Human CD58 Monoclonal Antibody (Biotin Conjugated, TS2/9.1) is a valuable tool for researchers investigating the role of CD58 in immune-mediated pathologies and developing novel immunotherapies targeting the CD58-CD2 interaction. Unlock the potential of CD58 research with this high-quality monoclonal antibody.

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Product Title:	Biotin Anti-Human CD58 Antibody [TS2/9.1]
SKU:	AGEL0272
Size:	25µg, 100µg
Clone No:	TS2/9.1
Synonyms:	Lymphocyte function-associated antigen 3;CD58;Ag3;Surface glycoprotein LFA-3;LFA3;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Biotin
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P19256
Gene ID:	965
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD58, also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is expressed on both hematopoietic and non-hematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of it's cognate ligand, CD2, on the T cell surface.

Biotin Anti-Human CD58 Antibody [TS2/9.1] (AGEL0272)

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Description