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Human ITGA5 Recombinant Protein (RPES1682)

SKU:
RPES1682
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
€236
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Description

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Human ITGA5 Recombinant Protein

Integrin ?-5 belongs to the Integrin ? chain family and contains 7 FG-GAP repeats. Integrin ?-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts; endothelial cells; peripheral T cells and platelets. Integrin ?-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion; ITGA5 participates in cell-surface mediated signalling.