Anti-Nectin 2/CD112 Antibody (CAB9622)

SKU:
CAB9622
€129 - €349

Description

Technical Manual

Anti-Nectin 2/CD112 Antibody

Product Name:Anti-Nectin 2/CD112 Antibody
Product SKU:CAB9622
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human Nectin 2/CD112
Sequence:

Email for sequence

Gene ID:5819
Swiss Prot:Q92692
Synonyms:CD112; HVEB; PRR2; PVRL2; PVRR2
Calculated MW:62-75kDa
Observed MW:72KDa
Reactivity:Human, Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry
Positive Samples:Jurkat, SH-SY5Y
Cellular Location:

Product Images

Anti-Nectin 2/CD112 Antibody (CAB9622)

Western blot - Nectin 2/CD112 Rabbit mAb (CAB9622)

Uniprot Information

UniProt Protein Function:Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
NCBI Summary:This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q92692
NCBI GenInfo Identifier:12643789
NCBI Gene ID:5819
NCBI Accession:Q92692.1
UniProt Secondary Accession:Q92692,O75455, Q6IBI6, Q96J29, A8K5L5,
UniProt Related Accession:Q92692
Molecular Weight:
NCBI Full Name:Nectin-2
NCBI Synonym Full Names:nectin cell adhesion molecule 2
NCBI Official Symbol:NECTIN2
NCBI Official Synonym Symbols:HVEB; PRR2; CD112; PVRL2; PVRR2
NCBI Protein Information:nectin-2
UniProt Protein Name:Nectin-2
UniProt Synonym Protein Names:Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Poliovirus receptor-related protein 2; CD_antigen: CD112
UniProt Gene Name:PVRL2
UniProt Entry Name:PVRL2_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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