Anti-KRT13 Antibody (CAB16393)
- SKU:
- CAB16393
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-KRT13 Antibody |
| Antibody SKU: | CAB16393 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-458 of human KRT13 (NP_705694.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-458 of human KRT13 (NP_705694.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DLTR VLAE MREQ YEAM AERN RRDA EEWF HAKS AELN KEVS TNTA MIQT SKTE ITEL RRTL QGLE IELQ SQLS MKAG LENT VAET ECRY ALQL QQIQ GLIS SIEA QLSE LRSE MECQ NQEY KMLL DIKT RLEQ EIAT YRSL LEGQ DAKM IGFP SSAG SVSP RSTS VTTT SSAS VTTT SNAS GRRT SDVR RP |
| Gene ID: | 3860 |
| Uniprot: | P13646 |
| Cellular Location: | |
| Calculated MW: | 38kDa/45kDa/49kDa |
| Observed MW: | 50kDa |
| Synonyms: | KRT13, CK13, K13, WSN2 |
| Background: | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. |
| UniProt Protein Function: | K13: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K4 |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: intermediate filament cytoskeleton; keratin filament; nucleus Biological Process: cytoskeleton organization and biogenesis Disease: White Sponge Nevus 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13646 |
| NCBI GenInfo Identifier: | 269849755 |
| NCBI Gene ID: | 3860 |
| NCBI Accession: | P13646.4 |
| UniProt Secondary Accession: | P13646,Q53G54, Q6AZK5, Q8N240, |
| UniProt Related Accession: | P13646 |
| Molecular Weight: | 45,867 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 13 |
| NCBI Synonym Full Names: | keratin 13 |
| NCBI Official Symbol: | KRT13Â Â |
| NCBI Official Synonym Symbols: | K13; CK13; WSN2Â Â |
| NCBI Protein Information: | keratin, type I cytoskeletal 13 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 13 |
| UniProt Synonym Protein Names: | Cytokeratin-13; CK-13; Keratin-13; K13 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT13Â Â |
| UniProt Entry Name: | K1C13_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using KRT13 Rabbit pAb (CAB16393) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using KRT13 antibody (CAB16393) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using KRT13 antibody (CAB16393) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of human placenta using KRT13 Polyclonal Antibody (CAB16393) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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