TRPC5 Antibody [N67/15 (Formerly sold as S67-15)] is a mouse monoclonal antibody directed against TRPC5, offered by Assay Genie for research applications. Reported applications include WB, IHC, IP and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b, purified by Protein G.
TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a non-selective, calcium-permeable ion channel belonging to the TRPC family of transient receptor potential channels. It forms functional homo- or hetero-multimeric complexes, particularly with TRPC1, and is activated by extracellular reduced thioredoxin—a redox-sensitive mechanism that links TRPC5 to oxidative stress signaling. TRPC5 is highly expressed in the brain, where it contributes to calcium homeostasis, synaptic plasticity, and neuronal excitability. It is involved in key processes such as fear response, dendritic spine remodeling, and neurodevelopment. Recent studies have also implicated TRPC5 in the modulation of anesthetic responses, including sensitivity to agents like chloroform, halothane, and propofol. In the context of neurodegenerative disease, TRPC5’s sensitivity to oxidative and inflammatory signals positions it as a potential mediator of neuronal injury. Dysregulated TRPC5 activity may exacerbate calcium overload, mitochondrial dysfunction, and excitotoxicity—hallmarks of conditions such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Given its dual role in redox signaling and calcium dynamics, TRPC5 is emerging as a promising target for therapeutic intervention in neurodegenerative and neuroinflammatory disorders. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
TRPC5 Antibody [N67/15 (Formerly sold as S67-15)]
Product SKU:
STMA00102
Size:
100 µg
Target:
TRPC5
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N67/15 (Formerly sold as S67-15)
Research Areas:
Neuroscience, Ion Channels, Transient Receptor Potential (TRP) Channels, Cell Signaling
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, IP, AM
Antibody Isotype:
IgG2b
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~110kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Immunogen Species:
Human
Accession Number:
NP_036603.1
Gene ID:
1919-10-11 00:00:00
Swiss-Prot:
Q9UL62
Cellular Localization:
Membrane
Alternative Names:
Htrp5, Short transient receptor potential channel 5, TRP5
References:
1. Xu S.Z., et al. (2008) Nature 451(7174): 69-72. 2. Bahnasi Y.M., et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.
