Anti-VDAC1 Antibody [N152B/23 (Formerly sold as S152B-23)]

VDAC1 Antibody [N152B/23 (Formerly sold as S152B-23)]

VDAC1 Antibody [N152B/23 (Formerly sold as S152B-23)] is a mouse monoclonal antibody directed against VDAC1, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein G.

Voltage-dependent anion-selective channel protein 1 (VDAC1), also known as mitochondrial porin 1, is a pivotal protein embedded in the outer mitochondrial membrane. It serves as the primary gateway for the exchange of ions and metabolites between mitochondria and the cytosol, playing a critical role in cellular energy metabolism, calcium homeostasis, and apoptosis. VDAC1 also functions as a docking site for key regulatory proteins, including hexokinase and BCL2L1, linking mitochondrial activity to glycolysis and cell survival pathways. In the context of neurodegenerative diseases, VDAC1 has emerged as a key player in mitochondrial dysfunction—a hallmark of disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Its involvement in the formation of the mitochondrial permeability transition pore complex (PTPC) facilitates the release of pro-apoptotic factors, triggering neuronal cell death. Dysregulation of VDAC1 expression or function has been associated with increased oxidative stress, impaired bioenergetics, and neuroinflammation. Given its central role in mitochondrial physiology and apoptosis, VDAC1 is increasingly recognized as a promising therapeutic target in neuroscience and neurodegeneration research. Understanding its molecular interactions and regulatory mechanisms may unlock new strategies for mitigating neuronal loss and preserving cognitive function. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.