Versican Antibody [N351/23 (Formerly sold as S351-23)]
Versican Antibody [N351/23 (Formerly sold as S351-23)] is a mouse monoclonal antibody directed against Versican, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
Versican (chondroitin sulfate proteoglycan 2, or CSPG2) is a large extracellular matrix (ECM) proteoglycan that plays a pivotal role in neural development, plasticity, and disease. As a key structural component of the brain’s ECM, Versican contributes to the formation of hydrated, viscoelastic matrices that regulate cell proliferation, migration, and differentiation. Its modular structure—featuring hyaluronic acid- and glycosaminoglycan-binding domains, EGF-like repeats, a lectin-like sequence, and a complement regulatory protein-like domain—enables dynamic interactions with neural cells and signaling molecules. Alternative splicing of the VCAN gene produces isoforms with distinct glycosaminoglycan modifications, influencing tissue-specific functions and pathological outcomes. In the central nervous system (CNS), Versican is increasingly recognized for its role in modulating neuroinflammation, glial scar formation, and synaptic remodeling—processes central to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Versican-rich pericellular matrices, often co-localized with hyaluronan, can alter cell adhesion and morphology, facilitating neural cell motility and mitosis. These properties are critical in both developmental neurobiology and the maladaptive responses seen in CNS injury and degeneration. Emerging evidence also links Versican dysregulation to impaired neural repair and chronic inflammation, positioning it as a potential biomarker and therapeutic target in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Versican Antibody [N351/23 (Formerly sold as S351-23)]
Product SKU:
STMA00139
Size:
100 µg
Target:
Versican
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N351/23 (Formerly sold as S351-23)
Research Areas:
Neuroscience, Cell Signaling, Scaffold Proteins
Buffer:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects >350kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein
