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Anti-c-Jun Antibody (CAB11378)

SKU:
CAB11378
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-c-Jun Antibody CAB11378
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-c-Jun Antibody CAB11378
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-c-Jun Antibody CAB11378
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-c-Jun Antibody CAB11378
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-c-Jun Antibody CAB11378
€139 - €419
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Description

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Antibody Name:Anti-c-Jun Antibody
Antibody SKU:CAB11378
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human c-Jun (NP_002219.1).
Application:WB IHC IF IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-1080, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human c-Jun (NP_002219.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTAK METT FYDD ALNA SFLP SESG PYGY SNPK ILKQ SMTL NLAD PVGS LKPH LRAK NSDL LTSP DVGL LK
Gene ID:3725
Uniprot:P05412
Cellular Location:Nucleus
Calculated MW:35kDa
Observed MW:43kDa
Synonyms:AP-1, AP1, c-Jun, JUN, c
Background:This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
UniProt Protein Function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
NCBI Summary:This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
UniProt Code:P05412
NCBI GenInfo Identifier:135298
NCBI Gene ID:3725
NCBI Accession:P05412.2
UniProt Secondary Accession:P05412,Q6FHM7, Q96G93,
UniProt Related Accession:P05412
Molecular Weight:
NCBI Full Name:Transcription factor AP-1
NCBI Synonym Full Names:jun proto-oncogene
NCBI Official Symbol:JUN  
NCBI Official Synonym Symbols:AP1; AP-1; c-Jun  
NCBI Protein Information:transcription factor AP-1
UniProt Protein Name:Transcription factor AP-1
UniProt Synonym Protein Names:Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Protein Family:C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name:JUN  
UniProt Entry Name:JUN_HUMAN
Anti-c-Jun Antibody (CAB11378)Western blot analysis of extracts of various cell lines, using c-Jun antibody (CAB11378) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-c-Jun Antibody (CAB11378)Immunohistochemistry of paraffin-embedded human tonsil using c-Jun antibody (CAB11378) at dilution of 1:100 (40x lens).
Anti-c-Jun Antibody (CAB11378)Immunohistochemistry of paraffin-embedded mouse testis using c-Jun antibody (CAB11378) at dilution of 1:100 (40x lens).
Anti-c-Jun Antibody (CAB11378)Immunohistochemistry of paraffin-embedded rat brain using c-Jun antibody (CAB11378) at dilution of 1:100 (40x lens).
Anti-c-Jun Antibody (CAB11378)Immunofluorescence analysis of C6 cells using c-Jun antibody (CAB11378) at dilution of 1:100. Blue: DAPI for nuclear staining.

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