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Anti-CEACAM6 Antibody (CAB8440)

SKU:
CAB8440
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
€139 - €419
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Description

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Antibody Name:Anti-CEACAM6 Antibody
Antibody SKU:CAB8440
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-320 of human CEACAM6 (NP_002474.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, Raji, HeLa, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-320 of human CEACAM6 (NP_002474.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LTLL SVKR NDAG SYEC EIQN PASA NRSD PVTL NVLY GPDV PTIS PSKA NYRP GENL NLSC HAAS NPPA QYSW FING TFQQ STQE LFIP NITV NNSG SYMC QAHN SATG LNRT TVTM ITVS G
Gene ID:4680
Uniprot:P40199
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:37kDa
Observed MW:110kDa
Synonyms:CEACAM6, CD66c, CEAL, NCA
Background:This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19.
UniProt Protein Function:CEACAM6: Belongs to the immunoglobulin superfamily. CEA family
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: cell-cell signaling; leukocyte migration; signal transduction

NCBI Summary:This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
UniProt Code:P40199
NCBI GenInfo Identifier:296439410
NCBI Gene ID:4680
NCBI Accession:P40199.3
UniProt Secondary Accession:P40199,Q13774, Q14920, Q53XP7,
UniProt Related Accession:P40199
Molecular Weight:37,195 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 6
NCBI Synonym Full Names:carcinoembryonic antigen related cell adhesion molecule 6
NCBI Official Symbol:CEACAM6  
NCBI Official Synonym Symbols:NCA; CEAL; CD66c  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 6
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 6
UniProt Synonym Protein Names:Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c
Protein Family:Carcinoembryonic antigen-related cell adhesion molecule
UniProt Gene Name:CEACAM6  
UniProt Entry Name:CEAM6_HUMAN
Anti-CEACAM6 Polyclonal Antibody (CAB8440)Western blot analysis of extracts of various cell lines, using CEACAM6 antibody (CAB8440) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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