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Epigenetics and Nuclear Signaling Antibodies 3 Anti-ATRX Antibody CAB17378
Key Features

ATRX Polyclonal Antibody (CAB17378)

Datasheet MSDS
SKU CAB17378
Product Type Antibody
Antibody Type Polyclonal Antibody
Reactivity Human, Mouse
Host Species Rabbit
Synonyms JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX, ATRX
Research Use Epigenetics and Nuclear Signaling
€96 - €370

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Description

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ATRX Polyclonal Antibody (CAB17378)

The ATRX Polyclonal Antibody (CAB17378) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, has high reactivity with human, mouse, and rat samples, and has been validated for use in various applications such as Western blot and immunohistochemistry.ATRX is known for its role in maintaining genome stability and telomere length, making it an important factor in cell proliferation and differentiation. Dysregulation of ATRX has been associated with various cancers, developmental disorders, and neurodegenerative diseases, highlighting its potential as a therapeutic target.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:ATRX Polyclonal Antibody
SKU:CAB17378
Size:20μL, 100μL
Reactivity:Human, Mouse
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:EEFN DETN VRGR LFII STKA GSLG INLV AANR VIIF DASW NPSY DIQS IFRV YRFG QTKP VYVY RFLA QGTM EDKI YDRQ VTKQ SLSF RVVD QQQV ERHF T
Tested Applications:WB ELISA
Recommended Dilution:
WB1:2000 - 1:6000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX, ATRX
Positive Sample:HeLa, Mouse brain
Cellular Localization:Nuclear Body, Nuclear Chromosome, Nucleoplasm, Nucleus, Pml Body.
Calculated MW:283kDa
Observed MW:310kDa

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Purification MethodAffinity purification
Gene ID546
RRIDAB_2768522
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
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