| UniProt Protein Function: | AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; TK group; Axl family Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cell surface; extracellular space; integral to plasma membrane; intracellular; plasma membrane Molecular Function:ATP binding; phosphatidylserine binding; protein binding; protein heterodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; viral receptor activity Biological Process: apoptotic cell clearance; blood vessel remodeling; cell maturation; cellular response to extracellular stimulus; entry of virus into host cell; erythrocyte homeostasis; forebrain cell migration; inflammatory response; innate immune response; natural killer cell differentiation; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptosis; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; platelet activation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling cascade; protein kinase B signaling cascade; secretion by cell; signal transduction; spermatogenesis; vagina development; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P30530 |
| NCBI GenInfo Identifier: | 239938818 |
| NCBI Gene ID: | 558 |
| NCBI Accession: | P30530.3 |
| UniProt Secondary Accession: | P30530,Q8N5L2, Q9UD27, |
| UniProt Related Accession: | P30530 |
| Molecular Weight: | 97,377 Da |
| NCBI Full Name: | Tyrosine-protein kinase receptor UFO |
| NCBI Synonym Full Names: | AXL receptor tyrosine kinase |
| NCBI Official Symbol: | AXLÂ Â |
| NCBI Official Synonym Symbols: | ARK; UFO; JTK11; Tyro7Â Â |
| NCBI Protein Information: | tyrosine-protein kinase receptor UFO |
| UniProt Protein Name: | Tyrosine-protein kinase receptor UFO |
| UniProt Synonym Protein Names: | AXL oncogene |
| Protein Family: | Tyrosine-protein kinase receptor |
| UniProt Gene Name: | AXLÂ Â |
| UniProt Entry Name: | UFO_HUMAN |
