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Anti-BIN3 Antibody (CAB15478)

SKU:
CAB15478
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-BIN3 Antibody
Antibody SKU:CAB15478
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human BIN3 (NP_061158.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, A431, HeLa, Mouse kidney, Mouse spleen, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human BIN3 (NP_061158.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSWI PFKI GQPK KQIV PKTV ERDF EREY GKLQ QLEE QTRR LQKD MKKS TDAD LAMS KSAV KISL DLLS NPLC EQDQ DLLN MVTA LDTA MKRM DAFN QEKV NQIQ KTVI EPLK KFGS VFPS LNMA VKRR EQAL QDYR RLQA KVEK YEEK EKTG PVLA KLHQ AREE LRPV REDF EAKN RQLL EEMP RFYG SRLD YFQP SFES LIRA QVVY YSEM HKIF GDLS HQLD QPGH SDEQ RERE NEAK LSEL RALS IVAD D
Gene ID:55909
Uniprot:Q9NQY0
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:23kDa/29kDa
Observed MW:35kDa
Synonyms:BIN3
Background:The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.
UniProt Protein Function:BIN3: Involved in cytokinesis and septation where it has a role in the localization of F-actin. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 8p21.3

Molecular Function:protein binding

Biological Process: protein localization; unidimensional cell growth

NCBI Summary:The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NQY0
NCBI GenInfo Identifier:30912742
NCBI Gene ID:55909
NCBI Accession:Q9NQY0.1
UniProt Secondary Accession:Q9NQY0,Q9BVG2, Q9NVY9,
UniProt Related Accession:Q9NQY0
Molecular Weight:23,218 Da
NCBI Full Name:Bridging integrator 3
NCBI Synonym Full Names:bridging integrator 3
NCBI Official Symbol:BIN3  
NCBI Protein Information:bridging integrator 3
UniProt Protein Name:Bridging integrator 3
Protein Family:Bridging integrator
UniProt Gene Name:BIN3  
UniProt Entry Name:BIN3_HUMAN
Anti-BIN3 Antibody (CAB15478)Western blot analysis of extracts of various cell lines, using BIN3 antibody (CAB15478) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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