Description

Biotin Anti-Human CD127/IL-7RA Antibody [A019D5]

The Anti-Human CD127 (IL-7RA) Antibody (A019D5) is a vital tool for researchers studying the CD127 protein, which is also known as the interleukin-7 receptor alpha (IL-7RA). This polyclonal antibody is specifically designed for applications in immunology and related fields.The CD127 protein is a crucial component of the immune system, playing a pivotal role in the development and function of various immune cells, particularly T cells. By targeting CD127, researchers can gain insights into immune cell activation, proliferation, and survival pathways. This antibody, produced using high-quality biotin, offers excellent specificity and sensitivity for detecting CD127 expression in human samples.Validated for use in a variety of experimental techniques, including immunohistochemistry and flow cytometry, the Anti-Human CD127 (IL-7RA) Antibody (A019D5) allows for detailed analysis of CD127 expression and localization within various cell types.

Its versatility and reliability make it an essential tool for investigating immune responses, cytokine signaling, and immune cell interactions.Researchers exploring topics such as autoimmune diseases, infectious disorders, and immune system dysregulation will find this antibody invaluable for advancing their understanding of CD127 biology and its implications in health and disease. By elucidating the functions of CD127, new therapeutic strategies may be developed to modulate immune responses and treat immune-related conditions effectively.

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Product Title:	Biotin Anti-Human CD127/IL-7RA Antibody [A019D5]
SKU:	AGEL3324
Size:	25µg, 100µg
Clone No:	A019D5
Synonyms:	Interleukin-7 receptor subunit alpha;IL-7RA;CDw127;CD127;IL-7Rα;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Biotin
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P16871
Gene ID:	3575
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Biotin Anti-Human CD127/IL-7RA Antibody [A019D5] (AGEL3324)

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Description