The Biotinylated Anti-41BB Ligand Antibody is a high-quality research tool designed for detecting and studying the 41BB Ligand protein in various cell types. This antibody, raised in rabbits, has been validated for use in applications such as Western blotting and immunohistochemistry, making it a versatile option for researchers in the fields of immunology and cancer research.41BB Ligand, also known as CD137L, is a co-stimulatory molecule involved in regulating immune responses and promoting T cell activation. It plays a crucial role in enhancing T cell survival, proliferation, and cytokine production, making it a valuable target for studying immune system modulation and developing immunotherapies for cancer and other diseases.
By using the Biotinylated Anti-41BB Ligand Antibody, researchers can accurately detect and analyze the expression of 41BB Ligand in various experimental settings, providing valuable insights into its function and potential as a therapeutic target. This antibody offers high specificity and sensitivity, ensuring reliable results for your research needs.
Product Code:
HDLA030
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM68
Synonyms:
4-1BB Ligand,TNFSF9,CD137L
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
